{"id":5639,"date":"2013-07-11T14:47:25","date_gmt":"2013-07-11T14:47:25","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/chronic-hbv-infection\/"},"modified":"2025-05-13T20:27:57","modified_gmt":"2025-05-13T20:27:57","slug":"chronic-hbv-infection","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/chronic-hbv-infection\/","title":{"rendered":"Diagnostic Criteria for Chronic HBV Infection"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Chronic HBV infection is a necroinflammatory disease of the liver caused by persistent infection with HBV, and can be categorized as hepatitis B e antigen (HBeAg) positive or negative. Inactive hepatitis B surface antigen (HBsAg) carriers have HBV infection of the liver without significant, ongoing necroinflammatory disease. HBV infection is resolved when there is no further virologic, biochemical, or histologic evidence of active viral infection or disease.<br \/>\n<!--more--><br \/>\nDiagnostic criteria related to HBV include the following:<\/p>\n<ul>\n<li><strong style=\"line-height: 1.3em;\">Chronic hepatitis B:<\/strong><span style=\"line-height: 1.3em;\"> HBsAg positive for more than six months, serum HBV DNA greater than 20,000 IU per mL (lower values of 2,000 to 20,000 IU per mL often occur with HBeAg-negative chronic hepatitis B), persistent or intermittent elevation in alanine transaminase (ALT) or aspartate transaminase (AST) levels, and liver biopsy showing chronic hepatitis with moderate or severe necroinflammation.<\/span><\/li>\n<li><strong style=\"line-height: 1.3em;\">Inactive HBsAg carrier state: <\/strong><span style=\"line-height: 1.3em;\">HBsAg positive for more than six months, HBeAg negative and anti-HBeAg positive, serum HBV DNA less than 2,000 IU per mL, persistently normal ALT and AST levels, liver biopsy confirming absence of significant hepatitis.<\/span><\/li>\n<li><strong style=\"line-height: 1.3em;\">Resolved hepatitis B:<\/strong><span style=\"line-height: 1.3em;\"> known history of acute or chronic hepatitis B or the presence of anti-hepatitis B core antigen (anti-HBcAg) with or without anti-HBsAg, HBsAg negative, undetectable serum HBV DNA (very low levels may be detectable with sensitive prostate-specific antigen assays), and normal ALT levels.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li><span style=\"line-height: 1.3em;\">Kuo A, Gish R. Chronic hepatitis B infection. Clin Liver Dis. 2012 May;16(2):347-69. <\/span><a style=\"line-height: 1.3em;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22541703\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li><span style=\"line-height: 1.3em;\">Liaw YF, Chu CM. Hepatitis B virus infection. Lancet. 2009;373:582\u201392. <\/span><a style=\"line-height: 1.3em;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19217993\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li><span style=\"line-height: 1.3em;\">Bonino F, Piratvisuth T, Brunetto MR, Liaw YF. Diagnostic markers of chronic hepatitis B infection and disease. Antivir Ther. 2010;15 Suppl 3:35-44. <\/span><a style=\"line-height: 1.3em;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21041902\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Jul 11, 2013.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[39],"tags":[146,16,15,145,14,13,1150,1144,266,267],"class_list":["post-5639","post","type-post","status-publish","format-standard","hentry","category-infetious-disease","tag-chronic","tag-criteria","tag-criterios","tag-cronica","tag-diagnostic","tag-diagnostico","tag-hbv","tag-hepatitis","tag-infeccion","tag-infection"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/5639","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=5639"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/5639\/revisions"}],"predecessor-version":[{"id":8836,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/5639\/revisions\/8836"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=5639"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=5639"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=5639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}