{"id":5684,"date":"2013-08-26T15:35:30","date_gmt":"2013-08-26T15:35:30","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/inherited-primary-hyperoxalurias\/"},"modified":"2025-05-13T20:27:53","modified_gmt":"2025-05-13T20:27:53","slug":"inherited-primary-hyperoxalurias","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/inherited-primary-hyperoxalurias\/","title":{"rendered":"Features and Treatment of the Inherited Primary Hyperoxalurias"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>The autosomal recessive inherited primary hyperoxalurias types I, II and III are caused by defects in glyoxylate metabolism that lead to the endogenous overproduction of oxalate.<br \/>\n<!--more--><br \/>\nPrimary hyperoxaluria should be considered in any patient with a history of recurrent calcium oxalate stones, nephrocalcinosis, or both.<\/p>\n<p><strong>Features and Treatment of the Inherited Primary Hyperoxalurias.<\/strong><\/p>\n<table border=\"1\" width=\"100%\" cellspacing=\"0\" cellpadding=\"4\">\n<colgroup>\n<col width=\"64*\" \/>\n<col width=\"64*\" \/>\n<col width=\"64*\" \/>\n<col width=\"64*\" \/> <\/colgroup>\n<tbody>\n<tr valign=\"TOP\">\n<td width=\"25%\"><strong>Feature <\/strong><\/td>\n<td width=\"25%\"><strong>Type 1 <\/strong><\/td>\n<td width=\"25%\"><strong>Type 2 <\/strong><\/td>\n<td width=\"25%\"><strong>Type 3 <\/strong><\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"25%\">Chromosomal location<\/td>\n<td width=\"25%\">2q37.3<\/td>\n<td width=\"25%\">9p13.2<\/td>\n<td width=\"25%\">10q24.2<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"25%\">Age at onset<\/td>\n<td width=\"25%\">All ages, although mostly in childhood<\/td>\n<td width=\"25%\">All ages<\/td>\n<td width=\"25%\">All ages<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"25%\">Presentation<\/td>\n<td width=\"25%\">Calcium oxalate renal stones, nephrocalcinosis, renal failure<\/td>\n<td width=\"25%\">Calcium oxalate renal stones<\/td>\n<td width=\"25%\">Calcium oxalate renal stones<\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" valign=\"TOP\" width=\"100%\">Treatment<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"25%\">Supportive treatment<\/td>\n<td width=\"25%\">Hydration, citrate, pyridoxine<\/td>\n<td width=\"25%\">Hydration, citrate<\/td>\n<td width=\"25%\">Hydration, citrate<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"25%\">Transplantation<\/td>\n<td width=\"25%\">Liver and kidney<\/td>\n<td width=\"25%\">Kidney<\/td>\n<td width=\"25%\">Not required &#8211; no reported cases of renal failure to date<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Cochat P, Rumsby G. Primary Hyperoxaluria. N Engl J Med. 2013 Aug 15;369(7):649-658. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23944302\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Hoppe B. An update on primary hyperoxaluria. Nat Rev Nephrol. 2012 Jun 12;8(8):467-75.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22688746\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Aug 26, 2013.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[473],"tags":[40,41,2047,2046,2045,2044,114,261,262],"class_list":["post-5684","post","type-post","status-publish","format-standard","hentry","category-nephrology","tag-caracteristicas","tag-features","tag-hiperoxalurias","tag-hyperoxalurias","tag-inherited","tag-primarias","tag-primary","tag-tratamiento","tag-treatment"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/5684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=5684"}],"version-history":[{"count":3,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/5684\/revisions"}],"predecessor-version":[{"id":9298,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/5684\/revisions\/9298"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=5684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=5684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=5684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}