{"id":5815,"date":"2019-12-12T00:49:27","date_gmt":"2019-12-12T00:49:27","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/?p=5815"},"modified":"2026-01-28T18:54:48","modified_gmt":"2026-01-28T18:54:48","slug":"allred","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/allred\/","title":{"rendered":"Allred Score for Estrogen and Progesterone Receptor Evaluation"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p><\/p>\n<p style=\"font-weight: 300;\">Breast cancer (BC) hormonal receptors status is assessed by immunohistochemistry (IHC), a specific, sensitive, and accessible method that guide breast cancer treatment.<!--more--><\/p>\n<p><strong>Reporting Results of Estrogen Receptor and Progesterone Receptor Testing<\/strong><\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 159px;\" border=\"1\">\n<tbody style=\"font-style: inherit; font-weight: inherit;\">\n<tr style=\"font-style: inherit; font-weight: inherit;\">\n<td style=\"font-style: inherit; height: 56px;\">\n<p style=\"font-style: inherit; font-weight: inherit;\"><strong>Result<\/strong><\/p>\n<\/td>\n<td style=\"font-style: inherit; height: 56px;\">\n<p style=\"font-style: inherit; font-weight: inherit;\"><strong>Criteria<\/strong><\/p>\n<\/td>\n<td style=\"font-style: inherit; height: 56px;\">\n<p style=\"font-style: inherit; font-weight: inherit;\"><strong>Comments<\/strong><\/p>\n<\/td>\n<\/tr>\n<tr style=\"font-style: inherit; font-weight: inherit;\">\n<td style=\"font-style: inherit; height: 55px;\">\n<p style=\"font-style: inherit; font-weight: inherit;\">Positive<\/p>\n<\/td>\n<td style=\"font-style: inherit; height: 55px;\">\n<p style=\"font-style: inherit; font-weight: inherit;\">Immunoreactive tumor cells present (&gt;\/=1%)<\/p>\n<\/td>\n<td style=\"font-style: inherit; height: 55px;\">\n<p style=\"font-style: inherit; font-weight: inherit;\"><span style=\"font-style: inherit; font-weight: inherit;\">The percentage of immunoreactive cells may be determined by visual estimation or quantitation. Quantitation can be provided by reporting the percentage of positive cells or by a scoring system, such as the Allred score or the H score.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr style=\"font-style: inherit; font-weight: inherit;\">\n<td style=\"font-style: inherit; height: 48px;\">\n<p style=\"font-style: inherit; font-weight: inherit;\">Negative<\/p>\n<\/td>\n<td style=\"font-style: inherit; height: 48px;\">\n<p style=\"font-style: inherit; font-weight: inherit;\">&lt;1% immunoreactive tumor cells present<\/p>\n<\/td>\n<td style=\"font-style: inherit; height: 48px;\">\n<p style=\"font-style: inherit; font-weight: inherit;\"><span style=\"font-style: inherit; font-weight: inherit;\">\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"font-weight: 300;\"><span style=\"font-style: inherit; font-weight: inherit;\"><br \/>\n<script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script><br \/>\n<ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-0127150553352455\" data-ad-slot=\"7834404329\"><\/ins><br \/>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script><br \/>\n<\/span><\/p>\n<p style=\"font-weight: 300;\"><b><strong style=\"font-style: inherit;\">Allred Score for Estrogen and Progesterone\u00a0Receptor Evaluation<\/strong><\/b><\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 168px;\" border=\"1\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 25%; text-align: center; height: 24px;\"><span style=\"font-style: inherit; font-weight: inherit;\"><strong>Positive Cells, %<\/strong><\/span><\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\"><span style=\"font-style: inherit; font-weight: inherit;\"><strong>Proportion Score<\/strong><\/span><\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\"><strong>Intensity<\/strong><\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\"><span style=\"font-style: inherit; font-weight: inherit;\"><strong>Intensity Score<\/strong><\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 25%; text-align: center; height: 24px;\">0<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">0<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">None<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">0<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 25%; text-align: center; height: 24px;\">&lt;1<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">1<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">Weak<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">1<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 25%; text-align: center; height: 24px;\">1-10<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">2<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">Intermediate<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">2<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 25%; text-align: center; height: 24px;\">11\u201333<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">3<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">Strong<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">3<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 25%; text-align: center; height: 24px;\">34\u201366<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">4<\/td>\n<td style=\"width: 25%; height: 24px;\"><\/td>\n<td style=\"width: 25%; height: 24px;\"><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 25%; text-align: center; height: 24px;\"><span style=\"font-style: inherit; font-weight: inherit;\">&gt;\/=<\/span>67<\/td>\n<td style=\"width: 25%; text-align: center; height: 24px;\">5<\/td>\n<td style=\"width: 25%; height: 24px;\"><\/td>\n<td style=\"width: 25%; height: 24px;\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"font-weight: 300;\">The Allred score combines the percentage of positive cells and the\u00a0intensity of the reaction product in most of the carcinoma. The 2\u00a0scores are added together for a final score with 8 possible values.\u00a0Scores of 0 and 2 are considered negative. Scores of 3-8 are\u00a0considered positive.<\/p>\n<p><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script><br \/>\n<ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-0127150553352455\" data-ad-slot=\"7834404329\"><\/ins><br \/>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script><br \/>\n<strong>H Score for Estrogen and Progesterone\u00a0Receptor Evaluation<\/strong><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr style=\"height: 23px;\">\n<td style=\"width: 33.3333%; height: 47px;\" rowspan=\"2\">Cell Signal<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 23px;\" colspan=\"2\">Calculation of H Score<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; text-align: center; height: 24px;\"><span style=\"font-style: inherit; font-weight: inherit;\">Percentage of Cells<\/span><\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 24px;\"><span style=\"font-style: inherit; font-weight: inherit;\">Value Multiplied<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px;\">Cells with no signal<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 24px;\">%<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 24px;\"><span style=\"font-style: inherit; font-weight: inherit;\">x0=<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px;\">Cells with weak signal<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 24px;\">%<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 24px;\">x1=<\/td>\n<\/tr>\n<tr style=\"height: 48px;\">\n<td style=\"width: 33.3333%; height: 48px;\">Cells with moderate signal<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 48px;\">%<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 48px;\"><span style=\"font-style: inherit; font-weight: inherit;\">x2=<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px;\">Cells with strong signal<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 24px;\">%<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 24px;\"><span style=\"font-style: inherit; font-weight: inherit;\">x3=<\/span><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 33.3333%; height: 24px;\">Total score =<\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><\/td>\n<td style=\"width: 33.3333%; height: 24px;\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"font-weight: 300;\">The H score is determined by multiplying the percentage of cells\u00a0demonstrating each intensity (scored from 0 to 3) and adding the\u00a0results. There are 300 possible values. In this system, &lt;1% positive\u00a0cells is considered to be a negative result.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol style=\"font-weight: 300;\">\n<li style=\"font-style: inherit; font-weight: inherit;\">Fitzgibbons PL, Dillon DA, Alsabeh R, Berman MA, Hayes DF, Hicks DG, Hughes KS, Nofech-Mozes S.\u00a0Template for reporting results of biomarker testing of specimens from patients with carcinoma of the breast.\u00a0Arch Pathol Lab Med. 2014 May;138(5):595-601.\u00a0<a style=\"font-style: inherit; font-weight: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24236805\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li style=\"font-style: inherit; font-weight: inherit;\">Dalto\u00e9 RD, Madeira KP, de Carvalho AA, de Rezende LC, Silva IV, Rangel LB. Evaluation of the progesterone receptor status in breast cancer using three different antibodies: a comparison by Allred score system.\u00a0Int J Clin Exp Pathol. 2013 Dec 15;7(1):331-9.\u00a0<a style=\"font-style: inherit; font-weight: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24427354\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li style=\"font-style: inherit; font-weight: inherit;\">Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC; American Society of Clinical Oncology; College of American Pathologists. American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med. 2010 Jul;134(7):e48-72.\u00a0<a style=\"font-style: inherit; font-weight: inherit;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20586616\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Ogawa A, Murata T, Yoshida M, Ohgi N, Hashiguchi H, Nakashoji A, Maeda H, Watase C, Iwamoto E, Takayama S. Evaluation of progesterone receptors with different cutoff values according to menopausal status in hormone-positive early breast cancer. Sci Rep. 2025 Nov 14;15(1):40023. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41238736\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Feb 06, 2018.<br \/>\nUp-date Jan 28, 2026.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[2082],"tags":[2077,2080,2078,161,160,2079,2081,445,597,596,450],"class_list":["post-5815","post","type-post","status-publish","format-standard","hentry","category-pathologic","tag-allred","tag-estrogen","tag-estrogenos","tag-evaluacion","tag-evaluation","tag-progesterona","tag-progesterone","tag-puntuacion","tag-receptor","tag-receptores","tag-score"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/5815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=5815"}],"version-history":[{"count":10,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/5815\/revisions"}],"predecessor-version":[{"id":10598,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/5815\/revisions\/10598"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=5815"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=5815"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=5815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}