{"id":7429,"date":"2020-03-06T21:52:37","date_gmt":"2020-03-06T21:52:37","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/?p=7429"},"modified":"2026-01-09T19:08:39","modified_gmt":"2026-01-09T19:08:39","slug":"clinical-coronavirus","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/clinical-coronavirus\/","title":{"rendered":"Clinical Characteristics of Coronavirus Disease (Covid-19)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>During the initial phase of the Covid-19 outbreak, the diagnosis of the disease was complicated by the diversity in symptoms and imaging findings and in the severity of disease at the time of presentation. <!--more--><\/p>\n<p>The Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Clinical Characteristics of Coronavirus Disease in China<\/strong><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\"><strong>Characteristic<\/strong><\/td>\n<td style=\"width: 35.7876%; height: 24px;\"><\/td>\n<\/tr>\n<tr style=\"height: 192px;\">\n<td style=\"width: 64.2124%; height: 192px;\">Age<br \/>\n* Median (yr)<br \/>\n* Distribution<br \/>\n&#8211; 0-14 yr<br \/>\n&#8211; 15-49 yr<br \/>\n&#8211; 50-64 yr<br \/>\n&#8211; \u226565 yr<\/td>\n<td style=\"width: 35.7876%; height: 192px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n47 (35-58)<br \/>\n<span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n0.9<br \/>\n55.1<br \/>\n28.9<br \/>\n15.1<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Female sex (%)<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\">41.9<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Smoking history (%)<br \/>\n* Never smoked<br \/>\n* Former smoker<br \/>\n* Current smoker<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n85.4<br \/>\n1.9<br \/>\n12.6<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Median incubation period (days)<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\">4 (2-7)<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Fever on admission<br \/>\n* Patients (%)<br \/>\n* Median temperature<br \/>\n* Distribution of temperature (%)<br \/>\n&#8211; &lt;37.5 \u00b0C<br \/>\n&#8211; 37.5-38.0 \u00b0C<br \/>\n&#8211; 38.1-39.0 \u00b0C<br \/>\n&#8211; &gt;39.0 \u00b0C<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n43.8<br \/>\n37.3 (36.7-38.0)<br \/>\n<span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n9.9<br \/>\n30.9<br \/>\n46.9<br \/>\n12.3<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Fever during hospitalization<br \/>\n* Patients (%)<br \/>\n* Median highest temperature (\u00b0C)<br \/>\n&#8211; &lt;37.5 \u00b0C<br \/>\n&#8211; 37.5-38.0 \u00b0C<br \/>\n&#8211; 38.1-39.0 \u00b0C<br \/>\n&#8211; &gt;39.0 \u00b0C<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n88.7<br \/>\n38.3 (37.8-38.9)<br \/>\n9.9<br \/>\n30.9<br \/>\n46.9<br \/>\n12.3<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Symptoms (%)<br \/>\n* Conjunctival congestion<br \/>\n* Nasal congestion<br \/>\n* Headache<br \/>\n* Cough<br \/>\n* Sore throat<br \/>\n* Sputum production<br \/>\n* Fatigue<br \/>\n* Hemoptysis<br \/>\n* Shortness of breath<br \/>\n* Nausea or vomiting<br \/>\n* Diarrhea<br \/>\n* Myalgia or arthralgia<br \/>\n* Chills<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n0.3<br \/>\n4.8<br \/>\n13.6<br \/>\n67.8<br \/>\n13.9<br \/>\n33.7<br \/>\n38.1<br \/>\n0.9<br \/>\n18.7<br \/>\n5.0<br \/>\n3.8<br \/>\n14.9<br \/>\n11.5<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Signs of infection (%)<br \/>\n* Throat congestion<br \/>\n* Tonsil swelling<br \/>\n* Enlargement of lymph nodes<br \/>\n* Rash<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n1.7<br \/>\n2.1<br \/>\n0.2<br \/>\n0.2<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Coexisting disorder (%)<br \/>\n* Any<br \/>\n* Chronic obstructive pulmonary disease<br \/>\n* Diabetes<br \/>\n* Hypertension<br \/>\n* Coronary heart disease<br \/>\n* Cerebrovascular disease<br \/>\n* Hepatitis B infection<br \/>\n* Cancer<br \/>\n* Chronic renal disease<br \/>\n* Immunodeficiency<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n23.7<br \/>\n1.1<br \/>\n7.4<br \/>\n15.0<br \/>\n2.3<br \/>\n1.4<br \/>\n2.1<br \/>\n0.9<br \/>\n0.7<br \/>\n0.2<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\"><strong>Radiologic findings<\/strong><\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Abnormalities on chest radiograph (%)<br \/>\n* Ground-glass opacity<br \/>\n* Local patchy shadowing<br \/>\n* Bilateral patchy shadowing<br \/>\n* Interstitial abnormalities<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\">59.1<br \/>\n20.1<br \/>\n28.1<br \/>\n36.5<br \/>\n4.4<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Abnormalities on chest CT (%)<br \/>\n* Ground-glass opacity<br \/>\n* Local patchy shadowing<br \/>\n* Bilateral patchy shadowing<br \/>\n* Interstitial abnormalities<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\">86.2<br \/>\n56.4<br \/>\n41.9<br \/>\n51.8<br \/>\n14.7<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\"><strong>Laboratory findings<\/strong><\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Median Pao2:Fio2 ratio<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\">3.9 (2.9-4.7)<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">White-cell count<br \/>\n* Median (per mm3)<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n4700 (3500-6000)<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Distribution (%)<br \/>\n* &gt;10,000 per mm3<br \/>\n* &lt;4000 per mm3<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n5.9<br \/>\n33.7<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Lymphocyte count<br \/>\n* Median (per mm3)<br \/>\n* Distribution (%)<br \/>\n&#8211; &lt;1500 per mm3<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n1000 \/(700-1300)<br \/>\n<span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n83.2<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Distribution of other findings (%)<br \/>\n* C-reactive protein \u226510 mg\/liter<br \/>\n* Procalcitonin \u22650.5 ng\/ml<br \/>\n* Lactate dehydrogenase \u2265250 U\/liter<br \/>\n* Aspartate aminotransferase &gt;40 U\/liter<br \/>\n* Alanine aminotransferase &gt;40 U\/liter<br \/>\n* Total bilirubin &gt;17.1 \u03bcmol\/liter<br \/>\n* Creatine kinase \u2265200 U\/liter<br \/>\n* Creatinine \u2265133 \u03bcmol\/liter<br \/>\n* D-dimer \u22650.5 mg\/liter<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n60.7<br \/>\n5.5<br \/>\n41.0<br \/>\n22.2<br \/>\n21.3<br \/>\n10.5<br \/>\n13.7<br \/>\n1.6<br \/>\n46.4<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\"><strong>Complications<\/strong><\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Septic shock (%)<br \/>\nAcute respiratory distress syndrome (%)<br \/>\nAcute kidney injury (%)<br \/>\nDisseminated intravascular coagulation (%)<br \/>\nRhabdomyolysis (%)<br \/>\nPhysician-diagnosed pneumonia (%)<br \/>\nMedian time until development of pneumonia (days)<br \/>\n* After initial Covid-19 diagnosis<br \/>\n* After onset of Covid-19 symptoms<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\">1.1<br \/>\n3.4<br \/>\n0.5<br \/>\n0.1<br \/>\n0.2<br \/>\n91.1<br \/>\n<span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n0 (0-1)<br \/>\n3 (1-6)<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 64.2124%; height: 24px;\">Clinical outcomes at data cutoff (%)<br \/>\n* Discharge from hospital<br \/>\n* Death<br \/>\n* Recovery<br \/>\n* Hospitalization<\/td>\n<td style=\"width: 35.7876%; height: 24px; text-align: center;\"><span style=\"color: #ffffff;\">&#8211;<\/span><br \/>\n5.0<br \/>\n1.4<br \/>\n0.8<br \/>\n93.6<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;10.1056\/NEJMoa2002032. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32109013\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Xu XW, Wu XX, Jiang XG, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ. 2020;368:m606. Published 2020 Feb 19. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32075786\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Yang W, Cao Q, Qin L, et al. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China. J Infect. 2020;S0163-4453(20)30099-2. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32112884\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Mar 06, 2020.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[39],"tags":[40,952,490,935,2123,2146,51,50],"class_list":["post-7429","post","type-post","status-publish","format-standard","hentry","category-infetious-disease","tag-caracteristicas","tag-characteristics","tag-clinical","tag-clinicas","tag-coronavirus","tag-covid-19","tag-disease","tag-enfermedad"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - 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