{"id":8,"date":"2009-02-13T18:46:00","date_gmt":"2009-02-13T18:46:00","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/carapt\/"},"modified":"2025-05-14T21:06:04","modified_gmt":"2025-05-14T21:06:04","slug":"carapt","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/carapt\/","title":{"rendered":"Diagnostic Criteria for Amiodarone-Induced Pulmonary Toxicity (APT)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>The clinical diagnosis of amiodarone-induced pulmonary toxicity (APT) requires two or more of the following criteria:<\/p>\n<ol>\n<li class=\"MsoNormal\">new onset of pulmonary symptoms such as dyspnea, cough, or pleuritic chest pain;<\/li>\n<li class=\"MsoNormal\">new chest radiographic abnormality such as an interstitial or alveolar infiltrate;<\/li>\n<li class=\"MsoNormal\">a decrease in the DLCO of 20% from the pretreatment value, or if none is available, a value less than 80% of predicted;<\/li>\n<li class=\"MsoNormal\">abnormal lung uptake with gallium-67 radioisotope; and<\/li>\n<li class=\"MsoNormal\">characteristic histologic changes of lung tissue obtained by bronchoscopic or open lung biopsy.<\/li>\n<\/ol>\n<p><!--more--><\/p>\n<p class=\"MsoNormal\">Exclusion of alternative etiologies such as congestive heart failure, infection, or malignancy.<\/p>\n<p class=\"MsoNormal\" style=\"margin: 5pt 0cm;\">DLCO= diffusion capacity of the lung for carbon monoxide<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p class=\"MsoNormal\"><strong>References:<\/strong><\/p>\n<ol>\n<li>\n<p class=\"MsoNormal\" style=\"margin: 5pt 0cm;\" align=\"left\">Dusman RE, Stanton MS, Miles WM, Klein LS, Zipes DP, Fineberg NS, Heger JJ. Clinical features of amiodarone-induced pulmonary toxicity. Circulation. 1990 Jul;82(1):51-9. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2364524\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/p>\n<\/li>\n<li>\n<p class=\"MsoNormal\" style=\"margin: 5pt 0cm;\" align=\"left\">Camus P, Martin WJ 2nd, Rosenow EC 3rd. Amiodarone pulmonary toxicity. Clin Chest Med. 2004 Mar;25(1):65-75. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15062598\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/p>\n<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: Nov 06, 2006<\/p>\n<p class=\"MsoNormal\" style=\"margin: 5pt 0cm;\">\n<p><\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>The clinical diagnosis of amiodarone-induced pulmonary toxicity (APT) requires two or more of the following criteria: new onset of pulmonary symptoms such as dyspnea, cough, or pleuritic chest pain; new chest radiographic abnormality such as an interstitial or alveolar infiltrate; a decrease in the DLCO of 20% from the pretreatment value, or if none is [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[26],"tags":[1956,1955,1954,1348,16,15,14,13,960,959,234,29,1953,1957],"class_list":["post-8","post","type-post","status-publish","format-standard","hentry","category-cardiology","tag-amiodarona","tag-amiodarone","tag-apt","tag-cardiology","tag-criteria","tag-criterios","tag-diagnostic","tag-diagnostico","tag-induced","tag-inducida","tag-pulmonar","tag-pulmonary","tag-toxicidad","tag-toxicity"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/8","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/8\/revisions"}],"predecessor-version":[{"id":9053,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/8\/revisions\/9053"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=8"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=8"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}