{"id":8441,"date":"2021-03-12T15:09:31","date_gmt":"2021-03-12T15:09:31","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/?p=8441"},"modified":"2026-01-06T20:37:28","modified_gmt":"2026-01-06T20:37:28","slug":"sle","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/sle\/","title":{"rendered":"EULAR\/ACR New Classification Criteria for Systemic Lupus Erythematosus (SLE)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>The new EULAR\/ACR classification criteria use anti-nuclear antibodies (ANA) as an entry criterion. (Non-infectious) fever is the one new criterion. All criteria items now have individual weights (from 2 to 10) and are structured in domains, within which only the highest item is counted. There is one common attribution rule, counting criteria only if there is no more likely alternative explanation. Ten points are sufficient for classification. The new criteria have reached a sensitivity of 96.1% and a specificity of 93.4%.<!--more--><\/p>\n<p><strong>Classification criteria for systemic lupus erythematosus.<\/strong><\/p>\n<p><strong>Entry criterion<\/strong><br \/>\nAnti-nuclear antibodies (ANA) at a titer of \u22651:80 on HEp-2 cells or an equivalent positive test (ever)<\/p>\n<ul>\n<li>if absent, do not classify as SLE<\/li>\n<li>If present, apply additive criteria<\/li>\n<\/ul>\n<p><strong>Additive criteria<\/strong><\/p>\n<ul>\n<li>Do not count a criterion if there is a more likely explanation the SLE.<\/li>\n<li>Occurrence of a criterion on at least one occasion is sufficient.<\/li>\n<li>SLE classification requires at least one clinical criterion and \u226510 points.<\/li>\n<li>Criteria need not occur simultaneously.<\/li>\n<li>Within each domain, only the highest weighted criterion is counted toward the total score\u00a7.<\/li>\n<\/ul>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 39.479%;\"><strong>Clinical domains and criteria<\/strong><\/td>\n<td style=\"width: 10.521%; text-align: center;\"><strong>Weight<\/strong><\/td>\n<td style=\"width: 39.885%;\"><strong>Immunology domains and criteria<\/strong><\/td>\n<td style=\"width: 10.115%; text-align: center;\"><strong>Weight<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\"><strong>Constitutional<\/strong><\/td>\n<td style=\"width: 10.521%;\"><\/td>\n<td style=\"width: 39.885%;\"><strong>Antiphospholipid antibodies<\/strong><\/td>\n<td style=\"width: 10.115%;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\">\n<ul>\n<li>Fever<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 10.521%; text-align: center;\">2<\/td>\n<td style=\"width: 39.885%;\">\n<ul>\n<li>Anti-cardiolipin antibodies OR<\/li>\n<li>Anti-\u00df2GP1 antibodies OR<\/li>\n<li>Lupus anticoagulant<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 10.115%; text-align: center;\">2<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\"><strong>Hematologic<\/strong><\/td>\n<td style=\"width: 10.521%;\"><\/td>\n<td style=\"width: 39.885%;\"><strong>Complement proteins<\/strong><\/td>\n<td style=\"width: 10.115%;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\">\n<ul>\n<li>Leukopenia<\/li>\n<li>Thrombocytopenia<\/li>\n<li>Autoimmune hemolysis<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 10.521%; text-align: center;\">3<br \/>\n4<br \/>\n4<\/td>\n<td style=\"width: 39.885%;\">\n<ul>\n<li>Low C3 OR low C4<\/li>\n<li>Low C3 AND low C4<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 10.115%; text-align: center;\">3<br \/>\n4<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\"><strong>Neuropsychiatric<\/strong><\/td>\n<td style=\"width: 10.521%;\"><\/td>\n<td style=\"width: 39.885%;\"><strong>SLE-specific\u00a0<\/strong><\/td>\n<td style=\"width: 10.115%;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\">\n<ul>\n<li>Delirium<\/li>\n<li>Psychosis<\/li>\n<li>Seizure<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 10.521%; text-align: center;\">2<br \/>\n3<br \/>\n5<\/td>\n<td style=\"width: 39.885%;\">\n<ul>\n<li>Anti-dsDNA antibodies* OR<\/li>\n<li>Anti-Smith antibody<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 10.115%; text-align: center;\">6<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\"><strong>Mucocutaneous<\/strong><\/td>\n<td style=\"width: 10.521%;\"><\/td>\n<td style=\"width: 50%;\" colspan=\"2\" rowspan=\"8\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\">\n<ul>\n<li>Non-scarring alopecia<\/li>\n<li>Oral ulcers<\/li>\n<li>Subacute cutaneous OR discoid lupus<\/li>\n<li>Acute cutaneous lupus<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 10.521%; text-align: center;\">2<br \/>\n2<br \/>\n4<br \/>\n6<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\"><strong>Serosal<\/strong><\/td>\n<td style=\"width: 10.521%;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\">\n<ul>\n<li>Pleural or pericardial effusion<\/li>\n<li>Acute pericarditis<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 10.521%; text-align: center;\">5<br \/>\n6<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\"><strong>Musculoskeletal<\/strong><\/td>\n<td style=\"width: 10.521%;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\">\n<ul>\n<li>Joint involvement<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 10.521%; text-align: center;\">6<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\"><strong>Renal<\/strong><\/td>\n<td style=\"width: 10.521%;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 39.479%;\">\n<ul>\n<li>Proteinuria &gt;0.5 g\/24 hs<\/li>\n<li>Renal biopsy Class II or V lupus nephritis<\/li>\n<li>Renal biopsy Class III or IV lupus nephritis<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 10.521%; text-align: center;\">4<br \/>\n8<\/p>\n<p style=\"text-align: center;\">10<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 100%; text-align: center;\" colspan=\"4\"><strong>Total score:<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Classify as Systemic Lupus Erythematosus with a score of 10 or more if entry criterion fulfilled.<\/p>\n<p>\u00a7Additional criteria items within the same domain will not be counted.<br \/>\n*Note: In an assay with at least 90% specificity against relevant disease controls.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Aringer M, Leuchten N, Johnson SR. New Criteria for Lupus. Curr Rheumatol Rep. 2020 May 13;22(6):18. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32405775\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstr\u00f8m K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirj\u00e1k L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kum\u00e1novics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, R\u00faa-Figueroa Fern\u00e1ndez \u00cd, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, D\u00f6rner T, Johnson SR. 2019 European League Against Rheumatism\/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019;78(9):1151\u20131159. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31383717\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, et al. European League Against Rheumatism\/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Arthritis Rheumatol. 2019;71(9):1400\u20131412. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31385462\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Mar 06, 2021.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[45],"tags":[423,166,167,16,15,1086,1085,422,1084,1083,1082,1081,1088],"class_list":["post-8441","post","type-post","status-publish","format-standard","hentry","category-rheumatology","tag-acr","tag-clasificacion","tag-classification","tag-criteria","tag-criterios","tag-eritematoso","tag-erythematosus","tag-eular","tag-les","tag-lupus","tag-sistemico","tag-sle","tag-systemic"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/8441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=8441"}],"version-history":[{"count":19,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/8441\/revisions"}],"predecessor-version":[{"id":9477,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/8441\/revisions\/9477"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=8441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=8441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=8441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}