{"id":8544,"date":"2021-04-23T13:46:50","date_gmt":"2021-04-23T13:46:50","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/?p=8544"},"modified":"2026-01-06T20:30:15","modified_gmt":"2026-01-06T20:30:15","slug":"cnl","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/es\/cnl\/","title":{"rendered":"Criterios Diagn\u00f3stico para Leucemia Neutrof\u00edlica Cr\u00f3nica (LNC)"},"content":{"rendered":"<div class=\"7ca9444b8380138fe077da07353677a4\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>La leucemia neutrof\u00edlica cr\u00f3nica (LNC) es una neoplasia mieloproliferativa (NMP) rara, a menudo agresiva, definida por leucocitosis neutrof\u00edlica madura persistente, hiperplasia de granulocitos de la m\u00e9dula \u00f3sea y hepatoesplenomegalia frecuente. El descubrimiento fundamental de mutaciones impulsoras oncog\u00e9nicas en el receptor 3 del factor estimulante de colonias (CSF3R) en la mayor\u00eda de los pacientes con LNC , proporcionando un biomarcador de diagn\u00f3stico y racionalizando el uso de focalizaci\u00f3n farmacol\u00f3gica.<!--more--><\/p>\n<p><strong>Criterios diagn\u00f3stico para leucemia neutrof\u00edlica cr\u00f3nica (LNC)<\/strong><\/p>\n<p>1. Recuento de gl\u00f3bulos blancos (RGB) en sangre perif\u00e9rica \u226525 x 10<sup>9<\/sup>\/L<\/p>\n<ul>\n<li>Los neutr\u00f3filos segmentados m\u00e1s formas en banda \u226580% de los gl\u00f3bulos blancos<\/li>\n<li>Precursores de neutr\u00f3filos (promielocitos, mielocitos y metamielocitos) &lt;10% de RGB<\/li>\n<li>Rara vez se observan mieloblastos<\/li>\n<li>Recuento de monocitos &lt;1 x 10<sup>9<\/sup>\/L<\/li>\n<li>Sin disgranulopoyesis<\/li>\n<\/ul>\n<p>2. M\u00e9dula \u00f3sea hipercelular<\/p>\n<ul>\n<li>Granulocitos neutr\u00f3filos aumentados en porcentaje y n\u00famero<\/li>\n<li>La maduraci\u00f3n de los neutr\u00f3filos parece normal<\/li>\n<li>Mieloblastos &lt;5% de las c\u00e9lulas nucleadas<\/li>\n<\/ul>\n<p>3. No cumple con los criterios de la OMS para BCR-ABL1, CML, PV, ET o PMF<br \/>\n4. Sin modificaci\u00f3n de PDGFRA, PDGFRB o FGFR1, o PCM1-JAK2<br \/>\n5. Presencia de CSF3R T618I u otra mutaci\u00f3n activa de CSF3R<br \/>\no<br \/>\nEn ausencia de una mutaci\u00f3n CSFR3R, neutrofilia persistente (al menos 3 meses), esplenomegalia y sin una causa identificable de neutrofilia reactiva, incluida la ausencia de una neoplasia de c\u00e9lulas plasm\u00e1ticas o, si est\u00e1 presente, la demostraci\u00f3n de clonalidad de las c\u00e9lulas mieloides mediante estudios citogen\u00e9ticos o moleculares.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Bibliograf\u00eda:<\/strong><\/p>\n<ol>\n<li>Szuber N, Elliott M, Tefferi A. Chronic neutrophilic leukemia: 2020 update on diagnosis, molecular genetics, prognosis, and management. Am J Hematol. 2020 Feb;95(2):212-224. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31769070\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016 May 19;127(20):2391-405.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31659364\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Creado Abr 22, 2021.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>La leucemia neutrof\u00edlica cr\u00f3nica (LNC) es una neoplasia mieloproliferativa (NMP) rara, a menudo agresiva, definida por leucocitosis neutrof\u00edlica madura persistente, hiperplasia de granulocitos de la m\u00e9dula \u00f3sea y hepatoesplenomegalia frecuente. El descubrimiento fundamental de mutaciones impulsoras oncog\u00e9nicas en el receptor 3 del factor estimulante de colonias (CSF3R) en la mayor\u00eda de los pacientes con LNC [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[171],"tags":[146,2355,16,15,145,14,13,2346,2351,2357,2356,2354],"class_list":["post-8544","post","type-post","status-publish","format-standard","hentry","category-hematology","tag-chronic","tag-cnl","tag-criteria","tag-criterios","tag-cronica","tag-diagnostic","tag-diagnostico","tag-leucemia","tag-leukemia","tag-lnc","tag-neutrofilica","tag-neutrophilic"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/8544","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/comments?post=8544"}],"version-history":[{"count":8,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/8544\/revisions"}],"predecessor-version":[{"id":8557,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/8544\/revisions\/8557"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/media?parent=8544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/categories?post=8544"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/tags?post=8544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}