{"id":93,"date":"2009-02-28T15:39:48","date_gmt":"2009-02-28T15:39:48","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/dbtinsulin\/"},"modified":"2025-05-14T19:11:56","modified_gmt":"2025-05-14T19:11:56","slug":"dbtinsulin","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/dbtinsulin\/","title":{"rendered":"Pharmacokinetics of Insulin Preparations"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p><figure id=\"attachment_6696\" aria-describedby=\"caption-attachment-6696\" style=\"width: 544px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/insulin.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-6696 size-full\" src=\"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/insulin.jpg\" alt=\"Pharmacokinetics of Insulin Preparations\" width=\"544\" height=\"354\" srcset=\"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/insulin.jpg 544w, https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/insulin-300x195.jpg 300w, https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/insulin-461x300.jpg 461w\" sizes=\"auto, (max-width: 544px) 100vw, 544px\" \/><\/a><figcaption id=\"caption-attachment-6696\" class=\"wp-caption-text\">Pharmacokinetics of Insulin Preparations<\/figcaption><\/figure><\/p>\n<p>Each insulin preparation has a different pharmacokinetic profile, i.e., onset, peak effect, and duration.<br \/>\n<!--more--><\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 481px;\" border=\"1\">\n<tbody>\n<tr style=\"height: 10px;\">\n<td style=\"width: 45.306%; height: 10px;\" valign=\"top\"><\/td>\n<td style=\"width: 54.3666%; height: 10px;\" colspan=\"3\" valign=\"top\">\n<p align=\"center\"><strong>Time of Action<\/strong><\/p>\n<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 45.306%; height: 24px;\" valign=\"top\"><strong>Preparation<\/strong><\/td>\n<td style=\"width: 11.3354%; height: 24px;\" align=\"center\" valign=\"top\"><strong>Onset, h<\/strong><\/td>\n<td style=\"width: 9.43669%; height: 24px;\" align=\"center\" valign=\"top\"><strong>Peak, h<\/strong><\/td>\n<td style=\"width: 33.5945%; height: 24px;\" align=\"center\" valign=\"top\"><strong>Effective Duration, h<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 99.6726%; height: 24px;\" colspan=\"4\" valign=\"top\">Short-acting, subcutaneous<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 45.306%; height: 24px;\" valign=\"top\">Lispro<\/td>\n<td style=\"width: 11.3354%; height: 24px;\" align=\"center\" valign=\"top\">&lt;0.25<\/td>\n<td style=\"text-align: center; width: 9.43669%; height: 24px;\" align=\"center\" valign=\"top\">0.5\u20131.5<\/td>\n<td style=\"width: 33.5945%; height: 24px;\" align=\"center\" valign=\"top\">3\u20134<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 45.306%; height: 24px;\" valign=\"top\">Aspart<\/td>\n<td style=\"width: 11.3354%; height: 24px;\" align=\"center\" valign=\"top\">&lt;0.25<\/td>\n<td style=\"width: 9.43669%; height: 24px;\" align=\"center\" valign=\"top\">0.5\u20131.5<\/td>\n<td style=\"width: 33.5945%; height: 24px;\" align=\"center\" valign=\"top\">3\u20134<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 45.306%; height: 24px;\" valign=\"top\">Glulisine<\/td>\n<td style=\"width: 11.3354%; height: 24px;\" align=\"center\" valign=\"top\">&lt;0.25<\/td>\n<td style=\"width: 9.43669%; height: 24px;\" align=\"center\" valign=\"top\">0.5\u20131.5<\/td>\n<td style=\"width: 33.5945%; height: 24px;\" align=\"center\" valign=\"top\">3\u20134<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 45.306%; height: 24px;\" valign=\"top\">Regular<\/td>\n<td style=\"width: 11.3354%; height: 24px;\" align=\"center\" valign=\"top\">0.5\u20131.0<\/td>\n<td style=\"width: 9.43669%; height: 24px;\" align=\"center\" valign=\"top\">2\u20133<\/td>\n<td style=\"width: 33.5945%; height: 24px;\" align=\"center\" valign=\"top\">4\u20136<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 99.6726%; height: 24px;\" colspan=\"4\" valign=\"top\">Short-acting, inhaled<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 45.306%; height: 24px;\" valign=\"top\">Inhaled regular insulin<\/td>\n<td style=\"width: 11.3354%; height: 24px;\" align=\"center\" valign=\"top\">&lt;0.25<\/td>\n<td style=\"width: 9.43669%; height: 24px;\" align=\"center\" valign=\"top\">0.5\u20131.5<\/td>\n<td style=\"width: 33.5945%; height: 24px;\" align=\"center\" valign=\"top\">4\u20136<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 99.6726%; height: 24px;\" colspan=\"4\" valign=\"top\">Long-acting<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 45.306%; height: 24px;\" valign=\"top\">NPH<\/td>\n<td style=\"width: 11.3354%; height: 24px;\" align=\"center\" valign=\"top\">1\u20134<\/td>\n<td style=\"width: 9.43669%; height: 24px;\" align=\"center\" valign=\"top\">6\u201310<\/td>\n<td style=\"width: 33.5945%; height: 24px;\" align=\"center\" valign=\"top\">10\u201316<\/td>\n<\/tr>\n<tr style=\"height: 27px;\">\n<td style=\"width: 45.306%; height: 27px;\" valign=\"top\">Detemir<\/td>\n<td style=\"width: 11.3354%; height: 27px;\" align=\"center\" valign=\"top\">1\u20134<\/td>\n<td style=\"width: 9.43669%; height: 27px;\" align=\"center\" valign=\"top\">\u2014<em><sup>a<\/sup><\/em><\/td>\n<td style=\"width: 33.5945%; height: 27px;\" align=\"center\" valign=\"top\">12\u201320<\/td>\n<\/tr>\n<tr style=\"height: 27px;\">\n<td style=\"width: 45.306%; height: 27px;\" valign=\"top\">Glargine<\/td>\n<td style=\"width: 11.3354%; height: 27px;\" align=\"center\" valign=\"top\">1\u20134<\/td>\n<td style=\"width: 9.43669%; height: 27px;\" align=\"center\" valign=\"top\">\u2014<em><sup>a<\/sup><\/em><\/td>\n<td style=\"width: 33.5945%; height: 27px;\" align=\"center\" valign=\"top\">24<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 45.306%; height: 24px;\" valign=\"top\">Degludec<\/td>\n<td style=\"width: 11.3354%; height: 24px;\" align=\"center\" valign=\"top\">1\u20134<\/td>\n<td style=\"width: 9.43669%; height: 24px;\" align=\"center\" valign=\"top\">\u2014<\/td>\n<td style=\"width: 33.5945%; height: 24px;\" align=\"center\" valign=\"top\">&gt;40<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 99.6726%; height: 24px;\" colspan=\"4\" valign=\"top\">Insulin Combinations<\/td>\n<\/tr>\n<tr style=\"height: 27px;\">\n<td style=\"width: 45.306%; height: 27px;\" valign=\"top\">75\/25\u201375% protamine lispro, 25% lispro<\/td>\n<td style=\"width: 11.3354%; height: 27px;\" align=\"center\" valign=\"top\">&lt;0.25<\/td>\n<td style=\"width: 9.43669%; height: 27px;\" align=\"center\" valign=\"top\">1.5 h<em><sup>b<\/sup><\/em><\/td>\n<td style=\"width: 33.5945%; height: 27px;\" align=\"center\" valign=\"top\">Up to 10\u201316<\/td>\n<\/tr>\n<tr style=\"height: 27px;\">\n<td style=\"width: 45.306%; height: 27px;\" valign=\"top\">70\/30\u201370% protamine aspart, 30% aspart<\/td>\n<td style=\"width: 11.3354%; height: 27px;\" align=\"center\" valign=\"top\">&lt;0.25<\/td>\n<td style=\"width: 9.43669%; height: 27px;\" align=\"center\" valign=\"top\">1.5 h<em><sup>b<\/sup><\/em><\/td>\n<td style=\"width: 33.5945%; height: 27px;\" align=\"center\" valign=\"top\">Up to 10\u201316<\/td>\n<\/tr>\n<tr style=\"height: 27px;\">\n<td style=\"width: 45.306%; height: 27px;\" valign=\"top\">50\/50\u201350% protamine lispro, 50% lispro<\/td>\n<td style=\"width: 11.3354%; height: 27px;\" align=\"center\" valign=\"top\">&lt;0.25<\/td>\n<td style=\"width: 9.43669%; height: 27px;\" align=\"center\" valign=\"top\">1.5 h<em><sup>b<\/sup><\/em><\/td>\n<td style=\"width: 33.5945%; height: 27px;\" align=\"center\" valign=\"top\">Up to 10\u201316<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 45.306%; height: 24px;\" valign=\"top\">70\/30\u201370% NPH, 30% regular insulin<\/td>\n<td style=\"width: 11.3354%; height: 24px;\" align=\"center\" valign=\"top\">0.5\u20131<\/td>\n<td style=\"width: 9.43669%; height: 24px;\" align=\"center\" valign=\"top\">Dual<\/td>\n<td style=\"width: 33.5945%; height: 24px;\" align=\"center\" valign=\"top\">10\u201316<\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<td style=\"width: 45.306%; height: 24px;\" valign=\"top\">50\/50\u201350% NPH, 50% regular insulin<\/td>\n<td style=\"width: 11.3354%; height: 24px;\" align=\"center\" valign=\"top\">0.5\u20131<\/td>\n<td style=\"width: 9.43669%; height: 24px;\" align=\"center\" valign=\"top\">Dual<\/td>\n<td style=\"width: 33.5945%; height: 24px;\" align=\"center\" valign=\"top\">10\u201316<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em><sup>a<\/sup><\/em>Glargine has minimal peak activity; detemir has some peak activity at 6\u201314 h.<br \/>\n<em><sup>b<\/sup><\/em>Dual: two peaks; one at 2\u20133 h; the second several hours later.<\/p>\n<p>&nbsp;<\/p>\n<p class=\"MsoNormal\"><strong>References: <\/strong><\/p>\n<ol style=\"font-weight: 400;\">\n<li>Hirsch IB. Insulin analogues.\u00a0N Engl J Med. 2005 Jan 13;352(2):174-83.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15647580\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>DeWitt DE, Hirsch IB. Outpatient insulin therapy in type 1 and type 2 diabetes mellitus: scientific review. JAMA. 2003 May 7;289(17):2254-64.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12734137\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Jonassen I, Havelund S, Ribel U, et al. Insulin degludec is a new generation ultra-long acting basal insulin with a unique mechanism of protraction based on multi-hexamer formation. Diabetes. 2010;59(Suppl 1):A11.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: Dic 31, 2008<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[626],"tags":[2001,211,2000,1999,1998,1997,1996,1995,1994,1993,1992,2002],"class_list":["post-93","post","type-post","status-publish","format-standard","hentry","category-diabetes","tag-detemir","tag-diabetes","tag-farmacocinetica","tag-glargina","tag-glargine","tag-glulisina","tag-insulin","tag-lisproglulisine","tag-nph","tag-pharmacokinetics","tag-pharmacology","tag-preparations"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/93","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=93"}],"version-history":[{"count":7,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/93\/revisions"}],"predecessor-version":[{"id":9397,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/93\/revisions\/9397"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=93"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=93"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=93"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}