{"id":9755,"date":"2022-07-06T15:41:44","date_gmt":"2022-07-06T15:41:44","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/?p=9755"},"modified":"2025-12-30T20:14:39","modified_gmt":"2025-12-30T20:14:39","slug":"leukemia-acml","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/leukemia-acml\/","title":{"rendered":"Diagnostic Criteria of Atypical Chronic Myeloid Leukemia (aCML)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Atypical chronic myelogenous leukemia (aCML), BCR\/ABL1 negative is a rare disorder classified into the category of myelodysplastic\/myeloproliferative neoplasms (MDS\/MPN), according to the 2016 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia. It is, by definition, a BCR-ABL1-negative clonal disorder sharing myelodysplastic and myeloproliferative features. <!--more--><\/p>\n<p><strong>Diagnostic Criteria of Atypical Chronic Myeloid Leukemia (aCML)<\/strong><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 25.2137%;\"><strong>Feature<\/strong><\/td>\n<td style=\"width: 74.7863%;\"><strong>WHO 2016<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">Ph chromosome<\/td>\n<td style=\"width: 74.7863%;\">Absent<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">BCR\/ABL1<\/td>\n<td style=\"width: 74.7863%;\">Absent<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">Leukocytosis<\/td>\n<td style=\"width: 74.7863%;\">Persistent (\u226513&#215;10<sup>9<\/sup>\/L)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">Basophil count<\/td>\n<td style=\"width: 74.7863%;\">&lt;2%<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">Monocyte count<\/td>\n<td style=\"width: 74.7863%;\">&lt;10% of leukocytes<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">Multilineage dysplasia<\/td>\n<td style=\"width: 74.7863%;\">Dyserythropoiesis and dysmegakaryopoiesis may be present<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">Dysgranulopoiesis<\/td>\n<td style=\"width: 74.7863%;\">Present<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">Immature granulocytes<\/td>\n<td style=\"width: 74.7863%;\">\u2265 10% leukocytes<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">Blasts<\/td>\n<td style=\"width: 74.7863%;\">&lt;20% (blood and bone marrow)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">Bone marrow cellularity<\/td>\n<td style=\"width: 74.7863%;\">Hypercellular bone marrow<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">Other molecular characteristics<\/td>\n<td style=\"width: 74.7863%;\">No rearrangements of PDGFRA, PDGFRB, FGFR1, and PCM1-JAK2<br \/>\nEmphasis on molecular changes (ETNK1, SETBP1)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 25.2137%;\">Other factors<\/td>\n<td style=\"width: 74.7863%;\">WHO criteria for other MPNs not met<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>FAB, French-American-British; WHO, World Health Organization; Ph, Philadelphia; MPN, myeloproliferative neoplasm; MPN, myeloproliferative neoplasm.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Diamantopoulos PT, Viniou NA. Atypical Chronic Myelogenous Leukemia, BCR-ABL1 Negative: Diagnostic Criteria and Treatment Approaches. Front Oncol. 2021 Nov 17;11:722507. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34868917\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Belkhair J, Raissi A, Elyahyaoui H, Ameur MA, Chakour M. Atypical chronic myeloid leukemia BCR-ABL 1 negative: A case report and literature review. Leuk Res Rep. 2019 May 25;12:100172. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31194134\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Jun 24, 2022.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[171],"tags":[2498,2495,2497,146,16,15,145,14,13,2346,2351,2496,2347,2284],"class_list":["post-9755","post","type-post","status-publish","format-standard","hentry","category-hematology","tag-acml","tag-atipica","tag-atypical","tag-chronic","tag-criteria","tag-criterios","tag-cronica","tag-diagnostic","tag-diagnostico","tag-leucemia","tag-leukemia","tag-lmca","tag-mieloide","tag-myeloid"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - 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