Los inhibidores de HMG CoA-reductasa o estatinas son claramente la clase más efectiva de medicamentos para reducir el colesterol LDL. Estas drogas se han asociado con un impacto beneficioso sobre la morbididad y mortalidad cardiovascular.
Eficacia Comparativa del Tratamiento con Estatinas
| % LDL Reduction | 25-32% | 31-39% | 37-45% | 48-52% | 55-60% | 60-63% |
| Lovastatina | 20 mg | 40 mg | 80 mg | |||
| Pravastatina | 20 mg | 40 mg | 80 mg | |||
| Simvastatina | 10 mg | 20 mg | 40 mg | 80 mg | ||
| Fluvastatina | 40 mg | 80 mg | ||||
| Atorvastatina | 10 mg | 20 mg | 40 mg | 80 mg | ||
| Rosuvastatina | 5 mg | 10 mg | 20 mg | 40 mg | ||
| Ezetimibe/Simvastatina | 10/10 | 10/20 | 10/40 | 10/80 |
Bibliografía:
- Cholesterol Treatment Trialists’ (CTT) Collaboration, Fulcher J, O’Connell R, Voysey M, Emberson J, Blackwell L, Mihaylova B, Simes J, Collins R, Kirby A, Colhoun H, Braunwald E, La Rosa J, Pedersen TR, Tonkin A, Davis B, Sleight P, Franzosi MG, Baigent C, Keech A. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials. Lancet. 2015 Apr 11;385(9976):1397-405 [Medline]
- Weng TC, Yang YH, Lin SJ, Tai SH. A systematic review and meta-analysis on the therapeutic equivalence of statins. J Clin Pharm Ther. 2010 Apr;35(2):139-51. [Medline]
- Nicholls SJ, Brandrup-Wognsen G, Palmer M, Barter PJ. Meta-analysis of comparative efficacy of increasing dose of Atorvastatin versus Rosuvastatin versus Simvastatin on lowering levels of atherogenic lipids (from VOYAGER). Am J Cardiol. 2010 Jan 1;105(1):69-76. [Medline]
Creado Oct 31, 2017.
