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Unifying Concepts

Relative Potencies of Systemic Glucocorticoids

Glucocorticosteroids are a product of the adrenal cortex and perform a staggering number of physiological effects essential for life. Their clinical use is largely predicated on their anti-inflammatory and immunosuppressive properties.

Glucocorticoid Approximate Equivalent dose (mg) Half-life (Biologic) hours
Short-Acting
Cortisone 25 8-12
Hydrocortisone 20 8-12
Intermediate-Acting
Methylprednisolone 4 18-36
Prednisolone 5 18-36
Prednisone 5 18-36
Triamcinolone 4 18-36
Long-Acting
Betamethasone 0,6 – 0,75 36-54
Dexamethasone 0,75 36-54

 

 

References:

  1. Zoorob RJ, Cender D. A different look at corticosteroids. Am Fam Physician. 1998 Aug;58(2):443-50. [Medline]

Created: April 5, 2005

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