Unifying Concepts

Classification of Neutrophilia

Primary (no other evident associated disease)

    • Hereditary neutrophilia
    • Chronic idiopathic neutrophilia
    • Chronic myelogenous leukemia (CML) and other myeloproliferative diseases
    • Familial myeloproliferative disease
    • Congenital anomalies and leukemoid reaction
    • Leukocyte adhesion deficiency (LAD)
    • Familial cold urticaria and leukocytosis


  • Infection
  • Stress neutrophilia
  • Chronic inflammation
  • Drug induced: Steroids, lithium, tetracycline, G-CSF.
  • Nonhematologic malignancy
  • Generalized marrow stimulation as in hemolysis
  • Asplenia and hyposplenism



  1. Kyono W, Coates TD. A practical approach to neutrophil disorders. Pediatr Clin North Am. 2002 Oct;49(5):929-71, viii. [Medline]


Created: Oct 23, 2005

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