Angioedema, also known as Quincke edema or “angioneurotic edema”, is defined as the localized nonpitting edema of deep dermal, subcutaneous, or submucosal tissues resulting from the increase in vascular permeability and extravasation of intravascular fluids; although it can coincide with urticaria in a histamine-mediated process, a differentiating feature is that urticarial wheals are limited to the mid and papillary dermis. Continue reading “Diagnosis of Hereditary Angioedema (HAE)”
Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death; it involves multiple organ systems, including the respiratory tract, gastrointestinal tract, and skin.
Continue reading “Diagnostic Criteria for Anaphylaxis”
Anaphylaxis can present with a spectrum of signs and symptoms affecting multiple organ systems, including the skin, gastrointestinal tract, cardiovascular system, nervous system, and both the upper and lower respiratory tracts; hallmarks of anaphylaxis are the development of hypotension or the involvement of more than one organ system.
Continue reading “Clinical Features of Anaphylaxis”