Unifying Concepts

ACR Criteria for the Classification of Hypersensitivity Vasculitis

Three of the following five criteria were required to meet American College of Rheumatology (ACR) classification criteria for hypersensitivity vasculitis:

  1. Age at disease onset older than 16 years.
  2. Medication at disease onset as a precipitating factor.
  3. Palpable purpura.
  4. Maculopapular rash.
  5. Biopsy specimen showing granulocytes around an arteriole and venule.

These criteria have a reported sensitivity of 71% and a reported specificity of 83.9% for the classification of hypersensitivity vasculitis compared with other vasculitides.




  1. Calabrese LH, Michel BA, Bloch DA, Arend WP, Edworthy SM, Fauci AS, et al. The American College of Rheumatology 1990 criteria for the classification of hypersensitivity vasculitis. Arthritis Rheum. 1990;33:1108-13.[Medline]


Created: May 29, 2005

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