Unifying Concepts

Clinical Conditions Associated with Disseminated Intravascular Coagulation (DIC)

DIC represents a continuum in clinical-pathological severity, characterised by the increasing loss of localisation or compensated control in intravascular activation of coagulation.

Clinical Conditions Associated with Disseminated Intravascular Coagulation (DIC)

1. Sepsis/severe infection (any microorganism)

2. Trauma (e.g., polytrauma, neurotrauma, fat embolism)

3. Organ destruction (e.g., severe pancreatitis)

4. Malignancy

  • solid tumors

  • myeloproliferative/lymphoproliferative malignancies

5. Obstetrical calamities

  • amniotic fluid embolism

  • abruptio placentae

6. Vascular abnormalities

  • Kasabach-Merritt syndrome

  • large vascular aneurysms

7. Severe hepatic failure

8. Severe toxic or immunologic reactions

  • snake bites

  • recreational drugs

  • transfusion reactions

  • transplant rejection




  1. Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M; Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001 Nov;86(5):1327-30. [Medline]


Created: Aug 04, 2005

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