Disseminated intravascular coagulation is a condition in which small blood clots develop throughout the bloodstream, blocking small blood vessels. The increased clotting depletes the platelets and clotting factors needed to control bleeding, causing excessive bleeding.
|Biological DIC||Hemostatic defect without clinical manifestations||
1 major criterion for consumption of platelets or coagulation factors
2 minor criteria for consumption of platelets or coagulation factors
|Clinical DIC||Hemostatic defect with hemorrhagic or ischemic manifestations||Same as above + microvascular bleeding and/or thrombosis|
|Complicated DIC||Hemostatic defect with hemorrhagic or ischemic manifestations that jeopardize organ function or patient prognosis||Same as above + organ failure (single or multiple)|
Details of laboratory criteria
D-Dimers greater than 500 µg·L–1
Minor: platelet count between 50 and 100,000·/mm3
Major: platelet count less than 50,000·/mm3
Consumption of coagulation factors
Minor: INR of the PT between 1.2 and 1.5
Major: INR of the PT greater than 1.5
INR of the PT = international normalized ratio of the prothrombin time. The elevation of D-Dimers is not specific to DIC. Similarly, the clinical manifestations of DIC are not specific.
- Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M; Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001 Nov;86(5):1327-30. [Medline]