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Unifying Concepts

Diagnostic Criteria for Tuberculosis Disease

Definite diagnosis

  • Clinical picture consistent with tuberculosis; bacteriologic confirmation (culture, gene probe/NAA + AFB smear); histologic findings

Probable diagnosis

  • Clinical picture consistent with tuberculosis; exclusion of other diagnostic considerations; presence of highly specific tuberculosis (surrogate) marker

Likely diagnosis

  • Clinical picture consistent with tuberculosis; exclusion of other diagnostic considerations; typical response to antituberculosis treatment (in absence of other treatment)

NOTE. AFB, acid-fast bacilli; NAA, nucleic acid amplification.

 

References:

  1. Glassroth J. Clinical considerations in designing trials of vaccines for tuberculosis. Clin Infect Dis. 2000 Jun;30 Suppl 3:S229-32. [Medline]

Created: Mar 04, 2008

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