Inclusion body myositis is the most common myopathy in patients over the age of 40 years encountered in neurological practice. Although it is usually sporadic, there is increasing awareness of the influence of genetic factors on disease susceptibility and clinical phenotype. The diagnosis is based on recognition of the distinctive pattern of muscle involvement and temporal profile of the disease, and the combination of inflammatory and myodegenerative changes and protein deposits in the muscle biopsy.
BMI is body weight divided by a power of height, usually (height)2, which is said to be independent of stature. Calculations based on values for ideal body weight suggest that BMIs for normal men and women should be in the range of 18.5 to 25 kg/m2. Indeed, this range roughly corresponds to the 10th to 75th percentile values recorded from adult individuals. For infants and children, average BMI values change with age, from 13 kg/m2 at birth, to a peak of 18 at about 1 year, a nadir of 15 at about age 6 years, and then a rise to adult values during adolescence.