Catatonia has a complex presentation that is composed of multiple signs and symptoms, of which only three need to be present for diagnosis. It may be thought of as occurring with schizophrenia or with mania; however, patients in other settings with various general medical health conditions may develop an episode of catatonia. It is essential to identify catatonia early on for treatment to protect the patient from developing any further complications. A number of medical conditions can mask catatonia, delaying its treatment.