An illness with the following clinical manifestations:
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Fever: temperature > 38.9º C (102º F)
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Rash: diffuse macular erythroderma
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Desquamation: 1-2 weeks after onset of illness, particularly palms and soles
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Hypotension: systolic blood pressure < 90 mm Hg for adults or less than fifth percentile by age for children <16 years of age; orthostatic drop in diastolic blood pressure greater than or equal to 15 mm Hg from lying to sitting, orthostatic syncope, or orthostatic dizziness