Unifying Concepts

Syndromes or Disease Entities That Have Been Associated with Polycystic Ovaries

A- Hyperandrogenism

o Steroidogenic enzyme deficiencies

§ Congenital adrenal hyperplasia

§ Aromatase deficiency

o Androgen-secreting tumors

§ Ovarian

§ Adrenal

o Exogenous androgens

§ Anabolic steroids

§ Transsexual hormone replacement

o Other

§ Acne

§ Idiopathic hirsutism

B- Hyperandrogenism and Insulin Resistance

o Congenital

§ Type A syndrome

§ Type B syndrome

§ Leprechaunism

§ Lipoatrophic diabetes

§ Rabson-Mendenhall syndrome

§ Polycystic ovary syndrome

o Acquired

§ Cushing’s syndrome

C- Insulin Resistance

o Glycogen storage diseases

o Type 2 diabetes

D- Other

o Central nervous system

§ Trauma/lesions

§ Hyperprolactinemia

o Nonhormonal medications

§ Valproate

o Heriditary angioedema

o Bulimia

o Idiopathic (includes normoandrogenic women with cyclic menses)



  1. The Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004 Jan;19(1):41-7. [Medline]
  2. Legro R. Diagnostic Criteria in Polycystic Ovary Syndrome. Semin Reprod Med. 2003 Aug;21(3):267-75 [Medline]
  3. Reaven G. The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals. Endocrinol Metab Clin North Am. 2004 Jun;33(2):283-303. [Medline]


Created: May 10, 2005

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