A- Hyperandrogenism
o Steroidogenic enzyme deficiencies
§ Congenital adrenal hyperplasia
§ Aromatase deficiency
o Androgen-secreting tumors
§ Ovarian
§ Adrenal
o Exogenous androgens
§ Anabolic steroids
§ Transsexual hormone replacement
o Other
§ Acne
§ Idiopathic hirsutism
B- Hyperandrogenism and Insulin Resistance
o Congenital
§ Type A syndrome
§ Type B syndrome
§ Leprechaunism
§ Lipoatrophic diabetes
§ Rabson-Mendenhall syndrome
§ Polycystic ovary syndrome
o Acquired
§ Cushing’s syndrome
C- Insulin Resistance
o Glycogen storage diseases
o Type 2 diabetes
D- Other
o Central nervous system
§ Trauma/lesions
§ Hyperprolactinemia
o Nonhormonal medications
§ Valproate
o Heriditary angioedema
o Bulimia
o Idiopathic (includes normoandrogenic women with cyclic menses)
References:
- The Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004 Jan;19(1):41-7. [Medline]
- Legro R. Diagnostic Criteria in Polycystic Ovary Syndrome. Semin Reprod Med. 2003 Aug;21(3):267-75 [Medline]
- Reaven G. The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals. Endocrinol Metab Clin North Am. 2004 Jun;33(2):283-303. [Medline]
Created: May 10, 2005