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The clinical diagnosis of amiodarone-induced pulmonary toxicity (APT) requires two or more of the following criteria:

1. new onset of pulmonary symptoms such as dyspnea, cough, or pleuritic chest pain;
2. new chest radiographic abnormality such as an interstitial or alveolar infiltrate;
3. a decrease in the DLCO of 20% from the pretreatment value, or if none is available, a value less than 80% of predicted;
4. abnormal lung uptake with gallium-67 radioisotope; and
5. characteristic histologic changes of lung tissue obtained by bronchoscopic or open lung biopsy.

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