Dry eye disease (DED) is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface.
Diagnostic Criteria of Dry Eye Disease
Comparison of Dry Eye Definition and Diagnostic Criteria Between JDES/ADES and DEWS II
| JDES/ADES | DEWS II | |
| Definition | A multifactorial disease characterized by unstable tear film causing a variety of symptoms and/or visual impairment, potentially accompanied by ocular surface damage. | A multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film, and accompanied by ocular symptoms, in which tear film instability and hyperosmolarity, ocular surface inflammation and damage, and neurosensory abnormalities play etiological roles. |
| Criteria | Presence of subjective symptom plus Break-Up Time (BUT) <5 seconds |
Positive symptomatology (Dry Eye Questionnaire-5 >5 or OSDI >13), plus noninvasive Break-Up Time (BUT) <10 seconds, or Osmolarity >308 mOsm/L or interocular difference >8 mOsm/L, or Ocular surface staining (>5 corneal spots, >9 conjunctival spots, or lid margin) |
References:
- Shimazaki J. Definition and Diagnostic Criteria of Dry Eye Disease: Historical Overview and Future Directions. Invest Ophthalmol Vis Sci. 2018 Nov 1;59(14):DES7-DES12. [Medline]
- Tsubota K, Pflugfelder SC, Liu Z, Baudouin C, Kim HM, Messmer EM, Kruse F, Liang L, Carreno-Galeano JT, Rolando M, Yokoi N, Kinoshita S, Dana R. Defining Dry Eye from a Clinical Perspective. Int J Mol Sci. 2020 Dec 4;21(23):9271. [Medline]
Created Jan, 16, 2023.
