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Polycythemia Vera Study Group (PVSG) Diagnostic Criteria for Essential Thrombocytopaenia (ET)

All of the following criteria must be fulfilled to make a diagnosis of ET

1. Platelet count greater than 600 x 10⁹/L

2. Hematocrit less than 40 or normal red blood cell mass

3. Stainable iron in the marrow or normal RBC mean corpuscular volume (If these measurements suggest iron deficiency, polycythemia vera cannot be excluded unless a trial of iron therapy fails to increase the red blood cell mass into the polycythemic range.)

4. No Philadelphia chromosome or bcr/abl gene rearrangement

5. Collagen fibrosis of the bone marrow absent or less than one third of the biopsy area without both marked splenomegaly and a leukoerythroblastic blood film

6. No cytogenetic or morphologic evidence for a myelodysplastic syndrome

7. No cause for a reactive thrombocytosis

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