Serrated polyposis syndrome (SPS) (previously hyperplastic polyposis) is defined by number and size of serrated polyps in the colon and rectum, but the definition is purely arbitrary and there is no known genotype.
SPS is associated with a high risk of colorectal cancer, not only in the affected patient, but also family members. The carcinogenesis can be rapid, with several series describing interval cancers occurring quickly.
poliposis
Revised Criteria for Hereditary Non-Polyposis Colorectal Cancer (Lynch Syndrome)
Amsterdam Criteria (1991)
Three or more relatives with colorectal cancer, plus all of the following:
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One affected patient should be a first-degree relative of the other two;
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Colorectal cancer should involve at least two generations;
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At least one case of colorectal cancer should have been diagnosed before the age of 50 years.