The revised clinical staging and immunological classification of HIV are designed to assist in clinical management of HIV, especially where there is limited laboratory capacity.
WHO immunological classification for established HIV infection
| HIV-associated immunodeficiency | Age-related CD4 values | |||
| <11 months (CD4 percent) |
12 to 35 months (CD4 percent) |
36 to 59 months (CD4 percent) |
>5 years (absolute number per mm3 or CD4 percent) | |
| None or not significant | >35 | >30 | >25 | >500 |
| Mild | 30 to 35 | 25 to 30 | 20 to 25 | 350 to 499 |
| Moderate | 25 to 29 | 20 to 24 | 15 to 19 | 200 to 349 |
| Severe | <25 | <20 | <15 | <200 or <15 percent |
CD4 cells expressed as number of cells per mm3 or percentage of total lymphocytes.
References:
- Centers for Disease Control and Prevention (CDC). Revised surveillance case definition for HIV infection–United States, 2014. MMWR Recomm Rep. 2014 Apr 11;63(RR-03):1-10. [Medline]
- WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. World Health Organization 2007
Created: Dec 27, 2018.
