1993 Revised Classification System for HIV Infection and Expanded AIDS Surveillance Case Definition for Adolescents and Adults

Clinical Categories

CD4+ T Cell Categories

A Asymptomatic, Acute (Primary) HIV or PGL

B Symptomatic, Not A or C Conditions

C AIDS-Indicator Conditions













PGL, progressive generalized lymphadenopathy.


Clinical Categories of HIV Infection

Category A: Consists of one or more of the conditions listed below in an adolescent or adult (>13 years) with documented HIV infection.

Conditions listed in categories B and C must not have occurred.

  • Asymptomatic HIV infection

  • Persistent generalized lymphadenopathy

  • Acute (primary) HIV infection with accompanying illness or history of acute HIV infection

Category B: Consists of symptomatic conditions in an HIV-infected adolescent or adult that are not included among conditions listed in clinical category C and that meet at least one of the following criteria: (1) The conditions are attributed to HIV infection or are indicative of a defect in cell-mediated immunity; or (2) the conditions are considered by physicians to have a clinical course or to require management that is complicated by HIV infection. Examples include, but are not limited to, the following:

  • Bacillary angiomatosis

  • Candidiasis, oropharyngeal (thrush)

  • Candidiasis, vulvovaginal; persistent, frequent, or poorly responsive to therapy

  • Cervical dysplasia (moderate or severe)/cervical carcinoma in situ

  • Constitutional symptoms, such as fever (38.5°C) or diarrhea lasting >1 month

  • Hairy leukoplakia, oral

  • Herpes zoster (shingles), involving at least two distinct episodes or more than one dermatome

  • Idiopathic thrombocytopenic purpura

  • Listeriosis

  • Pelvic inflammatory disease, particularly if complicated by tuboovarian abscess

  • Peripheral neuropathy

Category C: Conditions listed in the AIDS surveillance case definition.

  • Candidiasis of bronchi, trachea, or lungs

  • Candidiasis, esophageal

  • Cervical cancer, invasive

  • Coccidioidomycosis, disseminated or extrapulmonary

  • Cryptococcosis, extrapulmonary

  • Cryptosporidiosis, chronic intestinal (>1 month’s duration)

  • Cytomegalovirus disease (other than liver, spleen, or nodes)

  • Cytomegalovirus retinitis (with loss of vision)

  • Encephalopathy, HIV-related

  • Herpes simplex: chronic ulcer(s) (>1 month’s duration); or bronchitis, pneumonia, or esophagitis

  • Histoplasmosis, disseminated or extrapulmonary

  • Isosporiasis, chronic intestinal (>1 month’s duration)

  • Kaposi’s sarcoma

  • Lymphoma, Burkitt’s (or equivalent term)

  • Lymphoma, primary, of brain

  • Mycobacterium avium complex or M. kansasii, disseminated or extrapulmonary

  • Mycobacterium tuberculosis, any site (pulmonary or extrapulmonary)

  • Mycobacterium, other species or unidentified species, disseminated or extrapulmonary

  • Pneumocystis carinii pneumonia

  • Pneumonia, recurrent

  • Progressive multifocal leukoencephalopathy

  • Salmonella septicemia, recurrent

  • Toxoplasmosis of brain

  • Wasting syndrome due to HIV




  1. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Recomm Rep. 1992 Dec 18;41(RR-17):1-19. [Medline]

Created: Mar 26, 2007