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Criteria for Essential Tremor

Essential tremor is considered to be a tremor syndrome characterized by isolated bilateral upper-limb action tremor with a duration of at least 3 years, with or without tremor in other locations, such as head, larynx (voice tremor), or lower limbs.
Essential tremor frequently manifests with additional mild neurologic signs of diagnostic uncertainty, such as mild ataxia, questionably abnormal posturing of the limbs, or impaired memory. This presentation is classified as “essential tremor plus. Continue reading “Criteria for Essential Tremor”

Diagnostic Criteria for Essential Thrombocytosis (ET)

Essential Thrombocytosis (ET) is the only chronic myeloproliferative disorder (MPD) without a specific phenotype. Because isolated thrombocytosis can be the initial clinical manifestation of polycythemia vera (PV), primary myelofibrosis (PMF), or chronic myelogenous leukemia, ET is not only a diagnosis of exclusion, it should also not be considered a single disease entity. Continue reading “Diagnostic Criteria for Essential Thrombocytosis (ET)”

Diagnostic Criteria for Essential Thrombocytopaenia (ET)

Polycythemia Vera Study Group (PVSG) Diagnostic Criteria for Essential Thrombocytopaenia (ET)

All of the following criteria must be fulfilled to make a diagnosis of ET

  1. Platelet count greater than 600 x 109/L

  2. Hematocrit less than 40 or normal red blood cell mass

  3. Stainable iron in the marrow or normal RBC mean corpuscular volume (If these measurements suggest iron deficiency, polycythemia vera cannot be excluded unless a trial of iron therapy fails to increase the red blood cell mass into the polycythemic range.)

  4. No Philadelphia chromosome or bcr/abl gene rearrangement

  5. Collagen fibrosis of the bone marrow absent or less than one third of the biopsy area without both marked splenomegaly and a leukoerythroblastic blood film

  6. No cytogenetic or morphologic evidence for a myelodysplastic syndrome

  7. No cause for a reactive thrombocytosis

    Continue reading “Diagnostic Criteria for Essential Thrombocytopaenia (ET)”

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