Essential Thrombocytosis (ET) is the only chronic myeloproliferative disorder (MPD) without a specific phenotype. Because isolated thrombocytosis can be the initial clinical manifestation of polycythemia vera (PV), primary myelofibrosis (PMF), or chronic myelogenous leukemia, ET is not only a diagnosis of exclusion, it should also not be considered a single disease entity. Continue reading “Diagnostic Criteria for Essential Thrombocytosis (ET)”
Polycythemia Vera Study Group (PVSG) Diagnostic Criteria for Essential Thrombocytopaenia (ET)
All of the following criteria must be fulfilled to make a diagnosis of ET
Platelet count greater than 600 x 109/L
Hematocrit less than 40 or normal red blood cell mass
Stainable iron in the marrow or normal RBC mean corpuscular volume (If these measurements suggest iron deficiency, polycythemia vera cannot be excluded unless a trial of iron therapy fails to increase the red blood cell mass into the polycythemic range.)
No Philadelphia chromosome or bcr/abl gene rearrangement
Collagen fibrosis of the bone marrow absent or less than one third of the biopsy area without both marked splenomegaly and a leukoerythroblastic blood film
No cytogenetic or morphologic evidence for a myelodysplastic syndrome
No cause for a reactive thrombocytosis
Continue reading “Diagnostic Criteria for Essential Thrombocytopaenia (ET)”
Copyright by MedicalCriteria.com
