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Revised Diagnostic Criteria for Paraneoplastic Pemphigus (PNP)

Paraneoplastic pemphigus (PNP) is a rare and life-threatening autoimmune bullous disease that classically occurs in the setting of an underlying neoplasm. PNP is also known as paraneoplastic autoimmune multiorgan syndrome (PAMS) because of its varied mucocutaneous and systemic deleterious effects. Due to the variable disease characteristics and lack of formally accepted diagnostic criteria, PNP remains a diagnostic challenge for clinicians. Continue reading “Revised Diagnostic Criteria for Paraneoplastic Pemphigus (PNP)”

Revised Physical Diagnostic Criteria for Osteosarcopenic Obesity (OSO)

Osteosarcopenic obesity (OSO) syndrome describes the simultaneous deterioration of bone, muscle and excess fat, resulting in reduced functionality and systemic metabolic dysregulation. The key component contributing to this may be ectopic fat in the viscera, bone and muscle. Continue reading “Revised Physical Diagnostic Criteria for Osteosarcopenic Obesity (OSO)”

Revised Diagnostic Criteria for Neurofibromatosis Type 1 (NF1)

Neurofibromatosis type 1, inherited in an autosomal dominant pattern, is characterized by multiple café-au-lait macules (CALMs), skinfold freckling (more correctly termed lentiginous macules since they occur in non–sun exposed areas), iris Lisch nodules, tumors of the nervous system, and other features. Continue reading “Revised Diagnostic Criteria for Neurofibromatosis Type 1 (NF1)”

Revised McGeer Criteria for Respiratory Tract Infection Surveillance (RTIs)

The criteria that define infections for surveillance purposes were selected to increase the likelihood that the events captured by application of the definitions are true infections. Presentations of infection in older residents of long-term care facilities (LTCFs), may be atypical, so failure to meet surveillance definitions may not fully exclude the presence of infection. For this reason, the surveillance definitions presented here may not be adequate for real-time case finding, diagnosis, or clinical decision making (eg, antibiotic initiation). Separate clinical guidelines address early identification of infections and appropriate initiation of antibiotic therapy in LTCF residents, which are both important for impacting resident outcomes. Continue reading “Revised McGeer Criteria for Respiratory Tract Infection Surveillance (RTIs)”

Revised McGeer Criteria for Urinary Tract Infection Surveillance (UTIs)

The definitions for UTI presented here differ substantially from the original surveillance definitions1 for both (A) residents without an indwelling catheter and (B) residents with an indwelling catheter. The revised definitions take into account the low probability of UTI in residents without indwelling catheters if localizing symptoms are not present, as well as the need for microbiologic confirmation for diagnosis. Continue reading “Revised McGeer Criteria for Urinary Tract Infection Surveillance (UTIs)”

ACR Revised Criteria for Early Diagnosis of Knee Osteoarthritis (OA)

Osteoarthritis (OA) is cartilage failure resulting in joint pain and loss of joint functions. Knee OA is the OA of knee that mechanical forces have major effect on initiation and progression of it. Knee OA is the most common disease of knee especially in the middle to old ages. The most common findings in the history and physical examination of the patients with knee OA are mechanical knee pain, gelling knee pain, crepitus on knee motion, bony tenderness and bony enlargement in the joint line. During the flare up of Osteoarthritis, knee can show swelling due to joint effusion called “Hydrarthrosis” that is a mechanical type of synovial fluid. Continue reading “ACR Revised Criteria for Early Diagnosis of Knee Osteoarthritis (OA)”

Revised Diagnostic Criteria for Restless Legs Syndrome (RLS)

Restless legs syndrome (RLS), a neurological sensorimotor disease often profoundly disturbing sleep and quality of life has variable expression influenced by genetic, environmental and medical factors. The symptoms vary considerably in frequency from less than once a month or year to daily and severity from mildly annoying to disabling. Symptoms may also remit for various periods of time. Continue reading “Revised Diagnostic Criteria for Restless Legs Syndrome (RLS)”

Revised Criteria for Mild Cognitive Impairment (MCI)

Mild cognitive impairment (MCI) is a common condition in the elderly. It is characterized by deterioration of memory, attention, and cognitive function that is beyond what is expected based on age and educational level. MCI does not interfere significantly with individuals’ daily activities. Continue reading “Revised Criteria for Mild Cognitive Impairment (MCI)”

Revised Diagnostic Criteria of Vogt-Koyanagi-Harada Disease (VKHD)

Vogt-Koyanagi-Harada disease (VKHD) is a bilateral, chronic granulomatous panuveitis associated with central nervous system, auditory, and integumentary manifestations. Continue reading “Revised Diagnostic Criteria of Vogt-Koyanagi-Harada Disease (VKHD)”

Revised Diagnostic Criteria for Preeclampsia

Preeclampsia is a disorder of pregnancy associated with new-onset hypertension, which occurs most often after 20 weeks of gestation and frequently near term. Although often accompanied by new-onset proteinuria, hypertension and other signs or symptoms of preeclampsia may present in some women in the absence of proteinuria. Continue reading “Revised Diagnostic Criteria for Preeclampsia”

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