Plasma cell neoplasms including multiple myeloma (MM) and related terminally differentiated B-cell neoplasms are characterized by secretion of monoclonal immunoglobulin and stepwise development from a preneoplastic clonal B and/or plasma cell proliferation called monoclonal gammopathy of undetermined significance (MGUS). Diagnosis of these disorders requires integration of clinical, laboratory, and morphological features. Continue reading “IMWG Diagnostic Criteria for Multiple Myeloma and Related Plasma Cell Disorders”
The definition of plasma cell myeloma (PCM) has rested on identifying clinical and laboratory features that predict when a sufficient burden of plasma cells has accumulated that the patient will benefit from treatment.
Continue reading “Diagnostic Criteria for Plasma Cell Myeloma (PCM)”
Germ cell tumours of the testis are the commonest malignancy in men aged 20-40 years. Considerable therapeutic improvements in management—based on the cancer’s responsiveness to chemotherapy that contains platinum—mean that over 95% of these patients can now expect to be cured.
Continue reading “Staging and Risk Stratification of Germ-Cell Tumors”
Giant Cell Arteritis (GCA) is a systemic vasculitis of the medium and large sized vessels with a tendency to involve extracranial branches of the carotid arteries.
Continue reading “Revised Criteria for the Classification of Giant-Cell Arteritis (GCA)”