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IMWG Diagnostic Criteria for Multiple Myeloma and Related Plasma Cell Disorders

Plasma cell neoplasms including multiple myeloma (MM) and related terminally differentiated B-cell neoplasms are characterized by secretion of monoclonal immunoglobulin and stepwise development from a preneoplastic clonal B and/or plasma cell proliferation called monoclonal gammopathy of undetermined significance (MGUS). Diagnosis of these disorders requires integration of clinical, laboratory, and morphological features. Continue reading “IMWG Diagnostic Criteria for Multiple Myeloma and Related Plasma Cell Disorders”

The 2017 McDonald Criteria for Diagnosis of Multiple Sclerosis (MS)

The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. Continue reading “The 2017 McDonald Criteria for Diagnosis of Multiple Sclerosis (MS)”

Revised IMWG Diagnostic Criteria for Multiple Myeloma

This International Myeloma Working Group consensus updates the disease definition of multiple myeloma to include validated biomarkers in addition to existing requirements of attributable CRAB features (hypercalcaemia, renal failure, anaemia, and bone lesions).

Continue reading “Revised IMWG Diagnostic Criteria for Multiple Myeloma”

Kurtzke’s Expanded Disability Status Scale (EDSS)

The Expanded Disability Status Scale (EDSS), an accepted method of quantifying disability in Multiple Sclerosis (MS) consists of an eight-function system scale monitoring motor, sensory, cerebellar, brain stem, visual, bowel and bladder, pyramidal and other functions.
Continue reading “Kurtzke’s Expanded Disability Status Scale (EDSS)”

Diagnosis of Multiple Endocrine Neoplasia Syndromes

The multiple endocrine neoplasia (MEN) syndromes are rare autosomal-dominant conditions that predispose affected individuals to benign and malignant tumors of the pituitary, thyroid, parathyroids, adrenals, endocrine pancreas, paraganglia, or nonendocrine organs.

Continue reading “Diagnosis of Multiple Endocrine Neoplasia Syndromes”

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