Criteria

El Escorial Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis (ALS)

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The diagnosis of Amyotrophic Lateral Sclerosis (ALS) requires

A. the presence of:
(A:1) evidence of lower motor neuron (LMN) degeneration by clinical, electrophysiological or neuropathologic examination,
(A:2) evidence of upper motor neuron (UMN) degeneration by clinical examination, and
(A:3) progressive spread of symptoms or signs within a region or to other regions, as determined by history or examination, together with

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Diagnostic Criteria for Amiodarone-Induced Pulmonary Toxicity (APT)

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The clinical diagnosis of amiodarone-induced pulmonary toxicity (APT) requires two or more of the following criteria:

  1. new onset of pulmonary symptoms such as dyspnea, cough, or pleuritic chest pain;
  2. new chest radiographic abnormality such as an interstitial or alveolar infiltrate;
  3. a decrease in the DLCO of 20% from the pretreatment value, or if none is available, a value less than 80% of predicted;
  4. abnormal lung uptake with gallium-67 radioisotope; and
  5. characteristic histologic changes of lung tissue obtained by bronchoscopic or open lung biopsy.

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Diagnostic Criteria for Neurocysticercosis

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Neurocysticercosis is the most common helminthic infection of the CNS but its diagnosis remains difficult. Clinical manifestations are nonspecific, most neuroimaging findings are not pathognomonic, and some serologic tests have low sensitivity and specificity.

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