Sézary Syndrome corresponds to 3% of all cutaneous lymphomas, and it is characterized by a triad of manifestations: erythrodermia with pruritus, limphonodomegalia and atypical circulating lymphocytes (referred to as Sézary or Lutzner cells). Associated clinical manifestations include lagophthalmos, alopecia, palmoplantar hyperkeratosis and onycodystrophy. Erythrodermia may be the progression of previous patches and plaques, developing from idiopathic erythrodermia or emerging de novo.
Criteria
Summary of the ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce ASCVD
The updated American College of Cardiology/American Heart Association (ACC/AHA) Guideline on the Treatment of Blood Cholesterol (GTBC) has been long-awaited since the latest update of the Adult Treatment Panel III (ATP III) guidelines in 2004. The updated GTBC recommends a significant paradigm shift in lipid-loweringdrug therapy for atherosclerotic cardiovascular disease (ASCVD) risk reduction, which has led to questions regarding their content and their implementation.
Features of the Thalassemias
The thalassemias are a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin chains. Alpha thalassemia is caused by reduced or absent synthesis of alpha globin chains, and beta thalassemia is caused by reduced or absent synthesis of beta globin chains. Imbalances of globin chains cause hemolysis and impair erythropoiesis.
PET-CT indications
Positron emission tomography (PET) and computed tomography (CT) complement each other’s strengths in integrated PET/CT. Most PET/CT studies in oncology are performed with 18F-fluorodeoxyglucose (FDG). FDG is a glucose analogue that is taken up and trapped within viable cells. An increased glycolytic activity is a characteristic in many types of cancers resulting in avid accumulation of FDG. These tumours excel as “hot spots” in FDG-PET/CT imaging. FDG-PET/CT proved to be of high diagnostic value in staging and restaging of different malignant diseases, such as colorectal cancer, lung cancer, breast cancer, head and neck cancer, malignant lymphomas, and many more.
DSM-5 Diagnostic Criteria for Major Depressive Disorder
The diagnostic criteria for major depression in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), require the presence of either sadness or anhedonia with a total of five or more symptoms over a 2-week period.
Diagnostic Criteria for Vegetative State (VS)
A vegetative state is absence of responsiveness and awareness due to overwhelming dysfunction of the cerebral hemispheres, with sufficient sparing of the diencephalon and brain stem to preserve autonomic and motor reflexes and sleep-wake cycles.
Criteria for Diagnostic of Fat Embolism Syndrome (FES)
Fat embolism syndrome, a condition characterized by hypoxia, bilateral pulmonary infiltrates, and mental status change.
Diagnostic Criteria for Serotonin Syndrome (SS)
Serotonin syndrome is a potentially life-threatening condition resulting from increased CNS serotonergic activity that is usually drug related. Symptoms may include mental status changes, hyperthermia, and autonomic and neuromuscular hyperactivity.
Modified Khorana Risk Score for Prediction of Venous Thromboembolic Events (VTE) in Patients with Cancer
Risk assessment tools can incorporate multiple variables to identify patients or subpopulations at risk for events. A recently developed risk score can identify cancer patients at high risk for VTE using a combination of easily available clinical and laboratory variables.
Classifications of Acute Kidney Injury and Chronic Kidney Disease
Recently developed consensus functional definitions on the basis of specific changes in the serum creatinine concentration and urine volume now complement anatomical approaches to diagnosis.