Acne is a primary inflammatory disorder involving the pilosebaceous unit. The
pathogenesis is multifactorial, involving four key factors with interrelated mechanisms: increased sebum production, hyperkeratinization of the follicular infundibulum, inflammation, and Cutibacterium acnes (formerly Propionibacterium acnes). Continue reading
Tag Archives: Treatment
Summary of the ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce ASCVD
The updated American College of Cardiology/American Heart Association (ACC/AHA) Guideline on the Treatment of Blood Cholesterol (GTBC) has been long-awaited since the latest update of the Adult Treatment Panel III (ATP III) guidelines in 2004. The updated GTBC recommends a significant paradigm shift in lipid-loweringdrug therapy for atherosclerotic cardiovascular disease (ASCVD) risk reduction, which has led to questions regarding their content and their implementation.
Continue reading
Features and Treatment of the Inherited Primary Hyperoxalurias
The autosomal recessive inherited primary hyperoxalurias types I, II and III are caused by defects in glyoxylate metabolism that lead to the endogenous overproduction of oxalate.
Continue reading
Indications for Antiviral Treatment in Patients with Herpes Zoster
Primary infection with varicella–zoster virus (VZV) results in chickenpox, characterized by viremia with a diffuse rash and seeding of multiple sensory ganglia, where the virus establishes lifelong latency. Herpes zoster is caused by reactivation of latent VZV in cranial-nerve or dorsal-root ganglia, with spread of the virus along the sensory nerve to the dermatome.
Continue reading
Guidelines for the Treatment of Asymptomatic Primary Hyperparathyroidism
The finding of hypercalcemia on routine biochemical testing or in the evaluation of postmenopausal women with osteoporosis is typically the initial clue to the diagnosis of primary hyperparathyroidism. The total serum calcium level, which combines both the free and albumin-bound components of circulating calcium, should be adjusted for the level of albumin. Measurement of ionized calcium may be useful in selected cases, such as in patients with hyperalbuminemia, thrombocytosis, Waldenström’s macroglobulinemia, and myeloma; these patients may have elevated levels of total serum calcium, but normal levels of ionized serum calcium (artifactual hypercalcemia).
Continue reading
Diagnosis, Clinical Characteristics, and Treatment of Sarcoidosis
Diagnosis
-
-
Diagnosis of sarcoidosis is firm when chest radiographic evidence is accompanied by compatible clinical features and noncaseating granulomas on biopsy, with all other causes of granulomas ruled out.
-
Biopsy is indicated for all patients presumed to have sarcoidosis, except those with Löfgren’s syndrome.
-
Diagnosis and Indications for Treatment of Molluscum Contagiosum
Molluscum contagiosum is generally a benign disease consisting of pearly, flesh-colored, umbilicated skin lesions 2 to 5 mm in diameter with a characteristic dimple at the center. Continue reading
