The definition of plasma cell myeloma (PCM) has rested on identifying clinical and laboratory features that predict when a sufficient burden of plasma cells has accumulated that the patient will benefit from treatment.
Diagnostic
DSM-5 Diagnostic Criteria for Autism Spectrum Disorder (ASD)
The American Psychiatric Association has just published the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The diagnostic criteria for autism spectrum disorder has been modified based on the research literature and clinical experience.
Diagnostic Criteria of Familial Mediterranean Fever (FMF)
The diagnosis of familial Mediterranean fever (FMF) is based upon three factors: typical clinical manifestations, a positive response to colchicine therapy, and genetic testing, although currently available tests do not detect all mutations associated with FMF.
Diagnostic Criteria in Sézary’s Syndrome (SS)
Sézary Syndrome corresponds to 3% of all cutaneous lymphomas, and it is characterized by a triad of manifestations: erythrodermia with pruritus, limphonodomegalia and atypical circulating lymphocytes (referred to as Sézary or Lutzner cells). Associated clinical manifestations include lagophthalmos, alopecia, palmoplantar hyperkeratosis and onycodystrophy. Erythrodermia may be the progression of previous patches and plaques, developing from idiopathic erythrodermia or emerging de novo.
DSM-5 Diagnostic Criteria for Major Depressive Disorder
The diagnostic criteria for major depression in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), require the presence of either sadness or anhedonia with a total of five or more symptoms over a 2-week period.
Diagnostic Criteria for Vegetative State (VS)
A vegetative state is absence of responsiveness and awareness due to overwhelming dysfunction of the cerebral hemispheres, with sufficient sparing of the diencephalon and brain stem to preserve autonomic and motor reflexes and sleep-wake cycles.
Criteria for Diagnostic of Fat Embolism Syndrome (FES)
Fat embolism syndrome, a condition characterized by hypoxia, bilateral pulmonary infiltrates, and mental status change.
Diagnostic Criteria for Serotonin Syndrome (SS)
Serotonin syndrome is a potentially life-threatening condition resulting from increased CNS serotonergic activity that is usually drug related. Symptoms may include mental status changes, hyperthermia, and autonomic and neuromuscular hyperactivity.
Diagnostic Criteria for the Classification of Vocal Cord Dysfunction (VCD)
Vocal cord dysfunction (VCD) is a syndrome characterized by paroxysms of glottic obstruction due to true vocal cord adduction resulting in symptoms such as dyspnea and noisy breathing.
Diagnostic Scoring System for Disseminated Intravascular Coagulation (DIC)
Disseminated intravascular coagulation is a clinicopathological diagnosis of a disorder that is defined by the International Society on Thrombosis and Hemostasis (ISTH) as “an acquired syndrome characterized by the intravascular activation of coagulation with loss of localization arising from different causes”. This condition typically originates in the microvasculature and can cause damage of such severity that it leads to organ dysfunction. It can be identified on the basis of a scoring system developed by the ISTH.