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Diagnostic Criteria for Rheumatoid Cachexia

12 April, 2023

Cachexia in RA (rheumatoid cachexia, RC), is mainly characterized by loss of muscle mass, in particular appendicular lean mass (ALM), and associated with accumulated fat mass (FM), situated mainly in the trunk area, indicating a shift towards the development of abdominal obesity. The loss of body cell mass (BCM) consists of an important issue of concern for patients with RA. BCM consists primarily of muscle and visceral mass (erythrocytes, serum proteins, lymphocytes, etc.), and is the part of the body with the greatest metabolic activity (95% of the total activity), determining protein requirements, energy expenditure, and the metabolic response to stress.

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Diagnostic Criteria for Wasting Disease (Cachexia) in Adults

27 March, 2023

Cachexia, is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass. The prominent clinical feature of cachexia is weight loss in adults (corrected for fluid retention) or growth failure in children (excluding endocrine disorders). Anorexia, inflammation, insulin resistance and increased muscle protein breakdown are frequently associated with wasting disease. Wasting disease is distinct from starvation, age-related loss of muscle mass, primary depression, malabsorption and hyperthyroidism and is associated with increased morbidity. Continue reading “Diagnostic Criteria for Wasting Disease (Cachexia) in Adults”

Classification and Prognosis of Chronic Kidney Disease

2 March, 2023

CKD is defined as kidney damage or glomerular filtration rate (GFR) <60 mL/min/1.73 m(2) for 3 months or more, irrespective of cause. Kidney damage in many kidney diseases can be ascertained by the presence of albuminuria, defined as albumin-to-creatinine ratio >30 mg/g in two of three spot urine specimens. Continue reading “Classification and Prognosis of Chronic Kidney Disease”

Diagnostic Criteria of Dry Eye Disease

26 January, 2023

Dry eye disease (DED) is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface. Continue reading “Diagnostic Criteria of Dry Eye Disease”

Diagnostic Criteria for Orthorexia

26 December, 2022

Orthorexia nervosa describes a pathological obsession with proper nutrition that is characterized by a restrictive diet, ritualized patterns of eating, and rigid avoidance of foods believed to be unhealthy or impure. Although prompted by a desire to achieve optimum health, orthorexia may lead to nutritional deficiencies, medical complications, and poor quality of life. Continue reading “Diagnostic Criteria for Orthorexia”

Diagnostic Criteria for Symptomatic Neuroma

23 December, 2022

After nerve injury, disorganized or incomplete nerve regeneration may result in a neuroma. The true incidence of symptomatic neuroma is unknown, and the diagnosis has traditionally been made based on patient history, symptoms, physical examination, and the anatomic location of pain, along with response to diagnostic injection. Continue reading “Diagnostic Criteria for Symptomatic Neuroma”

Diagnostic Criteria for Chronic Pancreatitis

24 November, 2022

Chronic Pancreatitis (CP) is a debilitating disease that classically presents with recurrent bouts of acute pancreatitis, chronic abdominal pain as well as evidence of end organ damage. This is a result of extensive fibrosis and inflammation within the gland that eventually leads to both exocrine and endocrine insufficiency. Continue reading “Diagnostic Criteria for Chronic Pancreatitis”

Screening for Advanced Fibrosis Related to NAFLD/NASH

1 November, 2022

Approximately 37% of adults, and as many as 70% of individuals with type 2 diabetes (T2D), have nonalcoholic fatty liver disease (NAFLD). Nonalcoholic steatohepatitis (NASH), a subtype of NAFLD characterized by inflammation, ballooning, and Mallory’s hyaline on liver biopsy, can lead to hepatic fibrosis, cirrhosis, and hepatocellular cancer (HCC). Both NAFLD and NASH are also associated with an increased risk of cardiovascular disease, cardiovascular and liver-related mortality, and impaired health-related quality of life.  Continue reading “Screening for Advanced Fibrosis Related to NAFLD/NASH”

The Global Deterioration Scale for Primary Degenerative Dementia

19 October, 2022

The Global Deterioration Scale (GDS) provides caregivers an overview of the stages of cognitive function for those suffering from a primary degenerative dementia such as Alzheimer’s disease. It is broken down into 7 different stages. Stages 1-3 are the pre-dementia stages. Stages 4-7 are the dementia stages. Biginning in stage 5, an individual can no longer survive without assistance. Within the GDS, each stage is numbered (1-7), given a short title (i.e., Forgetfulness, Early Confusional, etc. followed by a brief listing of the characteristics for that stage. Caregivers can get a rough idea of where an individual is at in the disease process by observing that individual’s behavioral characteristics and comparing them to the GDS. For more specific assessments, use Brief Cognitive Rating Scale (BCRS) and the Functional Assessment Staging (FAST) measures.
Continue reading “The Global Deterioration Scale for Primary Degenerative Dementia”

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