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Diagnostic Criteria for Sporadic Creutzfeldt-Jakob Disease (sCJD)

Classic Creutzfeldt-Jakob Disease (CJD) is a human prion disease. It is a neurodegenerative disorder with characteristic clinical and diagnostic features. This disease is rapidly progressive and always fatal. Infection with this disease leads to death, usually within 1 year of onset of illness. The criteria for clinical diagnosis plus the CSF real-time quaking-induced conversion (RT-QuIC) accurately identifies patients with sCJD (sensitivity 97%, specificity 99%).
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Electrodiagnostic Criteria for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

These criteria are applied by testing the median, ulnar (stimulated below the elbow), peroneal (stimulated below the fibular head), and tibial nerves on one side of the body. During testing, limb temperature should be no less than 33°C at the palm and no less than 30°C at the external malleolus.

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Diagnostic Criteria of Acute Disseminated Encephalomyelitis (ADEM)

Acute Disseminated Encephalomyelitis (ADEM) is a brief but intense attack of inflammation (swelling) in the brain and spinal cord and occasionally the optic nerves that damages the brain’s myelin (the white coating of nerve fibers).

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Criterios Diagnóstico para Vértigo Posicional Paroxístico Benigno

Diagnostic Criteria for Benign Paroxysmal Positional Vertigo

  • Vertigo associated with a characteristic mixed torsional and vertical nystagmus provoked by the Dix-Hallpike test
  • A latency (typically of 1 to 2 seconds) between the completion of the Dix-Hallpike test and the onset of vertigo and nystagmus
  • Paroxysmal nature of the provoked vertigo and nystagmus (i.e., an increase and then a decline over a period of 10 to 20 seconds)
  • Fatigability (i.e., a reduction in vertigo and nystagmus if the Dix-Hallpike test is repeated)

Common Causes of Vertigo

Otologic disorders

  • Benign paroxysmal positional vertigo
  • Meniere´s disease (hydrops endolymphayic)
  • Vestibular neuronitis (labyrinthitis)

Neurologic disorders

  • Migraine-associated dizziness
  • Vertebrobasilar insufficiency
  • Panic disorders

Dix-Hallpike Maneover for Positional Nystagmus

Peripheral disorder Central disorder
Latent period before onset of positional nystagmus 2 to 20 seconds None
Duration of nystagmus Less than 1 minute Greater than 1 minute
Fatigability Fatiguing with repetition Nonfatiguing
Direction of nystagmus Only one type, usually horizontal/rotatory May change direction with a given head position
Intensity of vertigo Severe Less severe, sometimes none

 

References:

  1. Furman JM, Cass SP. Benign paroxysmal positional vertigo. N Engl J Med. 1999 Nov 18;341(21):1590-6. [Medline]

 

Created: Dic 23, 2005

 

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