diagnostico

Diagnostic Criteria for Essential Thrombocytopaenia (ET)

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Polycythemia Vera Study Group (PVSG) Diagnostic Criteria for Essential Thrombocytopaenia (ET)

All of the following criteria must be fulfilled to make a diagnosis of ET

  1. Platelet count greater than 600 x 109/L

  2. Hematocrit less than 40 or normal red blood cell mass

  3. Stainable iron in the marrow or normal RBC mean corpuscular volume (If these measurements suggest iron deficiency, polycythemia vera cannot be excluded unless a trial of iron therapy fails to increase the red blood cell mass into the polycythemic range.)

  4. No Philadelphia chromosome or bcr/abl gene rearrangement

  5. Collagen fibrosis of the bone marrow absent or less than one third of the biopsy area without both marked splenomegaly and a leukoerythroblastic blood film

  6. No cytogenetic or morphologic evidence for a myelodysplastic syndrome

  7. No cause for a reactive thrombocytosis

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Diagnostic Criteria for Heparin-Induced Thrombocytopenia (HIT)

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Diagnostic Criteria for Heparin-Induced Thrombocytopenia (HIT)

  • Heparin exposure >5 days
  • Relative thrombocytopenia: decrease in platelet count by 50% from baseline OR absolute thrombocytopenia: decrease in platelet count to less than 100 to 150 x 109/L
  • Absence of other causes of thrombocytopenia
  • Development of new thrombosis, or extension of pre-existing thrombosis, while receiving heparin therapy
  • Confirmation by laboratory testing
  • Return to normal platelet count when heparin is discontinued

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Diagnostic Criteria for Thromboangiitis Obliterans (Buerger’s Disease)

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Since specificity of Buerger’s disease is characterized by peripheral ischemia of an inflammatory nature and with a self-limiting course, diagnostic criteria should be discussed from clinical of view.

Several different criteria have been proposed for the diagnosis of thromboangiitis obliterans:

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Diagnostic Criteria of Infarction in MRI of the Brain in Acute Stroke

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Acute: Subtle low signal (hypointense) on T1, often difficult to see at this stage, and high signal (hyperintense) on spin density and/or T2-weighted and proton density-weighted images starting 8 h after onset; should follow vascular distribution. Mass effect maximal at 24 h, sometimes starting 2 h after onset, even in the absence of parenchymal signal changes. No parenchymal enhancement with paramagnetic contrast agent. Territorial intravascular paramagnetic contrast enhancement of “slow-flow” arteries in hyperacute infarcts; at 48 h, parenchymal and meningeal enhancement can be expected.

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Criteria for Diagnosis of Still’s Disease

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Yamaguchi criteria for classification of adult Still’s disease

Presence of 5 or more criteria, of which at least 2 are Major (96% sensitivity; 92% specificity)

Yamaguchi criteria for classification of adult Still’s disease
Presence of 5 or more criteria, of which at least 2 are Major (96% sensitivity; 92% specificity)

Major Criteria

  • Temperature of >39°C for >1 wk
  • Leukocytosis >10,000/mm3 with >80% PMNs
  • Typical rash
  • Arthralgias >2 wk

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Diagnostic Criteria for Tuberous Sclerosis Complex (TSC)

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The diagnostic criteria for tuberous sclerosis complex (TSC) were revised at the Tuberous Sclerosis Complex Consensus Conference, July 1998.

Definite TSC: Two major features or one major feature plus two minor features

Probable TSC: One major feature plus one minor feature

Possible TSC: One major feature or two or more minor features

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