The diagnosis of cystic fibrosis is based on clinical signs and symptoms consistent with the disease and objective evidence of cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction.
One or more typical phenotypic features of CF:
Chronic sinopulmonary disease
Characteristic gastrointestinal and nutritional abnormalities
Salt loss syndromes
Obstructive azoospermia
or
Fibromyalgia syndrome (FMS) is conceptualized as a chronic disorder characterized by widespread and persistent non-inflammatory musculoskeletal pain. Concomitant symptoms usually include fatigue, insomnia, morning stiffness, depression, anxiety, and cognitive problems (forgetfulness, concentration difficulties, mental slowness, memory and attention problems, etc.). Furthermore, the majority of FMS patients usually show predominantly negative affect, including neuroticism, alexithymia, and catastrophizing and impaired health-related quality of life.
A firm diagnosis requires that two major or one major and two minor criteria are satisfied, in addition to evidence of recent streptococcal infection.
Clinical and laboratory “low risk” criteria for children younger than 3 months with fever and no focus of infection
Clinical criteria
Centers for Disease Control Diagnostic Criteria
Clinically evaluated, unexplained, persistent, or relapsing fatigue that is:
The diagnosis of a Functional Esophageal Disorder always presumes the absence of a structural or biochemical explanation for the symptoms.
The diagnosis of infective endocarditis is generally based on clinical, microbiologic, and echocardiographic findings. The Duke criteria have sensitivity and specificity of more than 80% and are the reference criteria for diagnosis.
Acute Respiratory Distress Syndrome (ARDS) is a syndrome of inflammation and increased permeability associated with a constellation of clinical, radiologic, and physiologic abnormalities unexplained by elevations in left atrial or pulmonary capillary pressure.
Definitive diagnosis
Male or female patient with reduced numbers of CD3+ T cells (less than 500/mm3) and two of the three following characteristics:
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