Periprosthetic joint infection (PJI) is a serious and potentially devastating complication that can occur after joint replacement surgery, such as hip or knee replacement. It refers to the presence of an infection in or around the artificial joint (prosthesis) that has been implanted during the surgical procedure.
Continue reading “Diagnostic Criteria of Periprosthetic Joint Infection (PJI)”
Visual loss describes temporary or permanent reduction in visual acuity and/or field. Its aetiology is diverse due to the contributions of the different neuro-ophthalmic structures (eye, optic nerve, and brain) to image formation and perception, but may be categorised into ocular causes (corneal, lenticular, vitreoretinal and macular) or optic neuropathies. Continue reading “Clinical Approach to Vision Loss”
The Confusion Assessment Method (CAM) is a widely used diagnostic tool for identifying delirium. It was developed by researchers at the Yale University School of Medicine and has become the gold standard for diagnosing delirium in clinical settings. The CAM helps healthcare professionals systematically evaluate and identify the presence of delirium based on four key features. Continue reading “Confusion Assessment Method (CAM) for Diagnosing Delirium”
The SARC-F questionnaire is a screening tool that can be rapidly implemented by clinicians to identify probable sarcopenic patients. The questionnaire screens patients for self-reported signs suggestive of sarcopenia, which include deficiencies in strength, walking, rising from a chair, climbing stairs, and experiencing falls. Each of the self-reported parameters receives a minimum and maximum score of 0 and 2, respectively, with the greatest maximum SARC-F score being 10. Continue reading “SARC-F Questionnaire for Sarcopenia”
The Edmonton Frail Scale (EFS) is an index used to measure alterations related to frailty. The EFS assesses nine subscales (1) cognition; (2) general health status; (3) functional independence; (4) social support; (5) medication use; (6) nutrition; (7) mood; (8) continence; and (9) functional performance (in 11 items). Continue reading “Edmonton Frail Scale (EFS)”
Maturity-onset diabetes of the young (MODY) is an autosomal dominantly inherited type of diabetes that results from heterozygous mutations in various transcription factors acting in the development and maturation of pancreatic β-cells. In addition, mutations in enzymes involved in glucose sensing of the β-cell have also been shown to result in early-onset diabetes. Characteristic features of MODY are autosomal inheritance, early onset of diabetes (with diagnosis generally before the age of 25 years), no signs related to the autoimmune process or insulin resistance, and preservation of endogenous insulin secretion. Continue reading “MODY subtypes: gene mutations, pathophysiology, and clinical characteristics”
The diagnostic criteria for ABPA include a history of asthma, evidence of Aspergillus fumigatus (A. fumigatus) IgE sensitisation on blood and/or skin tests, elevated total IgE levels and eosinophil counts, detection of Aspergillus precipitins or IgG, isolation of A. fumigatus in sputum cultures, presence of pulmonary infiltrates on chest x rays and distribution of bronchiectasis on CT chest scans. Continue reading “Diagnostic Criteria for Allergic Bronchopulmonary Aspergillosis (ABPA)”
The definition for a bronchiectasis exacerbation was agreed as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; haemoptysis AND a clinician determines that a change in bronchiectasis treatment is required. Continue reading “Definition of Bronchiectasis Pulmonary Exacerbation”
Kocher identified four predictive factors that can aid in differentiating septic arthritis of the hip from transient synovitis. Fever >38.5 C, inability to bear weight, serum white blood cell count (WBC) >12,000/mm3, and an erythrocyte sedimentation rate (ESR) ≥40 mm/h were found to be associated with septic arthritis of the hip. The presence of all four factors was 99.6% predictive of septic hip. Continue reading “Kocher Criteria for Septic Arthritis”
Cachexia in RA (rheumatoid cachexia, RC), is mainly characterized by loss of muscle mass, in particular appendicular lean mass (ALM), and associated with accumulated fat mass (FM), situated mainly in the trunk area, indicating a shift towards the development of abdominal obesity. The loss of body cell mass (BCM) consists of an important issue of concern for patients with RA. BCM consists primarily of muscle and visceral mass (erythrocytes, serum proteins, lymphocytes, etc.), and is the part of the body with the greatest metabolic activity (95% of the total activity), determining protein requirements, energy expenditure, and the metabolic response to stress.
Continue reading “Diagnostic Criteria for Rheumatoid Cachexia”
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