Unexplained Fever in Young Children

Clinical and laboratory “low risk” criteria for children younger than 3 months with fever and no focus of infection

Clinical criteria

  • Born at term (gestational age >/= 37 weeks)with uncomplicated nursery stay
  • Previously healthy infants
  • Notoxic manifestations
  • No focal bacterial infection (except otitis media)

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Diagnostic Criteria for Chronic Fatigue Syndrome (CFS)

Centers for Disease Control Diagnostic Criteria

Clinically evaluated, unexplained, persistent, or relapsing fatigue that is:

  • Of new or definite onset
  • Not a result of ongoing exertion
  • Not alleviated by rest
  • Results in a substantial reduction in previous levels of occupational, social, or personal activity

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Diagnostic Criteria for Necrotizing Enterocolitis (NEC)

Necrotizing enterocolitis is among the most common and devastating diseases in neonates. The excessive inflammatory process initiated in the highly immunoreactive intestine in necrotizing enterocolitis extends the effects of the disease systemically, affecting distant organs such as the brain and placing affected infants at substantially increased risk for neurodevelopmental delays.

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Appropriate Indications for Upper Gastrointestinal Endoscopy (UGE)

Upper gastrointestinal endoscopy is a standard technique that provides direct visualization of the gastrointestinal tract from the esophagus through the stomach, duodenal bulb, and descending duodenum.

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Modified Duke Criteria for the Clinical Diagnosis of Infective Endocarditis (IE)

The diagnosis of infective endocarditis is generally based on clinical, microbiologic, and echocardiographic findings. The Duke criteria have sensitivity and specificity of more than 80% and are the reference criteria for diagnosis.

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Light Criteria for Exudative Pleural Effusion

Transudative and exudative pleural effusions are distinguished by measuring the lactate dehydrogenase (LDH) and protein levels in the pleural fluid. Exudative pleural effusions meet at least one of the following criteria, whereas transudative pleural effusions meet none:

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Diagnostic Criteria for Adult Respiratory Distress Syndrome (ARDS)

Acute Respiratory Distress Syndrome (ARDS) is a syndrome of inflammation and increased permeability associated with a constellation of clinical, radiologic, and physiologic abnormalities unexplained by elevations in left atrial or pulmonary capillary pressure.

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Diagnostic Criteria for Diastolic Heart Failure

Diastolic heart failure is defined as a condition caused by increased resistance to the filling of one or both ventricles; this leads to symptoms of congestion from the inappropriate upward shift of the diastolic pressure-volume relation.

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