Classic Creutzfeldt-Jakob Disease (CJD) is a human prion disease. It is a neurodegenerative disorder with characteristic clinical and diagnostic features. This disease is rapidly progressive and always fatal. Infection with this disease leads to death, usually within 1 year of onset of illness. The criteria for clinical diagnosis plus the CSF real-time quaking-induced conversion (RT-QuIC) accurately identifies patients with sCJD (sensitivity 97%, specificity 99%).
Disease
Guidelines for Diagnosis of Moyamoya Disease
Moyamoya disease is a cerebrovascular condition predisposing affected patients to stroke in association with progressive stenosis of the intracranial internal carotid arteries and their proximal branches.
Diagnostic Criteria for Wilson’s disease
Wilson’s disease is clinically characterised by hepatic and neurological manifestations related to the accumulation of copper in the liver and the lenticular nuclei, and by Kayser-Fleischer rings.
Diagnostic Criteria for Tuberculosis Disease
Definite diagnosis
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Clinical picture consistent with tuberculosis; bacteriologic confirmation (culture, gene probe/NAA + AFB smear); histologic findings
Diagnostic Criteria for Thromboangiitis Obliterans (Buerger’s Disease)
Since specificity of Buerger’s disease is characterized by peripheral ischemia of an inflammatory nature and with a self-limiting course, diagnostic criteria should be discussed from clinical of view.
Several different criteria have been proposed for the diagnosis of thromboangiitis obliterans:
Criteria for Diagnosis of Still’s Disease
Yamaguchi criteria for classification of adult Still’s disease
Presence of 5 or more criteria, of which at least 2 are Major (96% sensitivity; 92% specificity)
Yamaguchi criteria for classification of adult Still’s disease
Presence of 5 or more criteria, of which at least 2 are Major (96% sensitivity; 92% specificity)
Major Criteria
- Temperature of >39°C for >1 wk
- Leukocytosis >10,000/mm3 with >80% PMNs
- Typical rash
- Arthralgias >2 wk
International Clinical Diabetic Retinopathy and Diabetic Macular Edema Disease Severity Scales
The levels in this new diabetic retinopathy disease severity scale consist of five scales with increasing risks of retinopathy.
CDC Diagnostic Criteria for the Diagnosis of Pelvic Inflammatory Disease (PID)
Minimal criteria*
- Lower abdominal tenderness
- Uterine/adnexal tenderness
- Cervical motion tenderness
Diagnostic Criteria for Parkinson’s Disease (PD)
United Kingdom Parkinson’s Disease Society Brain Bank Diagnostic Criteria for Parkinson’s Disease
Step 1: Diagnosis of Parkinsonism
Bradykinesia and at least one of the following:
Syndromes or Disease Entities That Have Been Associated with Polycystic Ovaries
A- Hyperandrogenism
o Steroidogenic enzyme deficiencies
§ Congenital adrenal hyperplasia
§ Aromatase deficiency
o Androgen-secreting tumors
§ Ovarian
§ Adrenal
o Exogenous androgens
§ Anabolic steroids
§ Transsexual hormone replacement
o Other
§ Acne
§ Idiopathic hirsutism